Archive · 2026-W32

Mito.news 2026-W32

71 articles. Each URL is the original /articles/{id} path.

• biorxiv2026-08-03score 93

  Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…

  Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-29score 91

  Why this mitochondrial dysfunction preprint matters: Novel in vivo measurement of muscle total carnitine concentration reveals potential mechanism linking mitochondrial dysf

  This medrxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Dysfunction-adjacent signals: dysfunction, disease context.

• medrxiv2026-08-06score 86

  GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype

  Scientific focus: OXPHOS, metabolism, therapeutics, structural biology. Core claim (from abstract): Objectives To characterize the hepatic histological, ultrastructural, and molecular phenotype of GRO at bariatric surgery, determine its recovery following surgery, and identify preoperative hepatic biomarkers associated with postoperative weight loss. Dysfunction linkage: mitochondrial dysfunction; OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-08-03score 83

  Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

  Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 83

  Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)

  Scientific focus: redox biology, metabolism, therapeutics, computational. Core claim (from abstract): Metabolic perturbation, mitochondrial dysfunction, and oxidative stress are key contributors to FSHD pathology. Dysfunction linkage: mitochondrial dysfunction; oxidative stress; reactive oxygen species; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-28score 83

  Why this mitochondrial dysfunction preprint matters: Protein Phosphatase 2A Activation Attenuates Acute Myocardial Injury in Takotsubo Syndrome by Modulating Ferroptosis and

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, aging. Dysfunction-adjacent signals: dysfunction, disease context.

• biorxiv2026-07-25score 83

  Why this mitochondrial dysfunction preprint matters: Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in

  This biorxiv preprint matters for mitochondria agents because it engages neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, disease context.

• biorxiv2026-08-03score 82

  Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, immunology. Core claim (from abstract): In pancreas tissue from donors across the natural history of T1D, we utilized an in-situ, whole - islet phenotypical and transcriptomic approach to unravel novel targets in the glucose-stimulus coupled secretion pathway that are similarly impaired in T-cell infiltrated and non-infiltrated islets. Dysfunction linkage: mitochondrial dysfunction; functional impairment; bioenergetics; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 82

  The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy

  Scientific focus: cardiovascular, structural biology, computational. Core claim (from abstract): Variants in SMYD1, a striated muscle-specific lysine methyltransferase critical for cardiac development and mitochondrial function, have only recently been linked to human cardiomyopathy. Dysfunction linkage: mitochondrial dysfunction; functional impairment; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-30score 81

  Why this mitochondrial dysfunction preprint matters: Data-Driven Biological Subtypes of Parkinson ′ s Disease

  This medrxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, aging. Dysfunction-adjacent signals: dysfunction, mtDNA, disease context, neurodegeneration.

• biorxiv2026-08-07score 78

  Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

  Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-04score 78

  Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma

  Scientific focus: apoptosis, metabolism, immunology, cancer. Core claim (from abstract): Here we report that peripheral CD8⁺ T lymphocytes in osteosarcoma patients are less frequent in circulation, hypo-producers of effector cytokines (IFN-γ and TNF-α), and have compromised metabolic fitness․ We characterized and investigated the effect of a panel of microbiota-derived GAMs on CD8⁺ T lymphocytes, confirming their immunomodulatory role with respect to CD8⁺ T lymphocytes activation, cellular metabolism and effector functions․ Indole-3-lactic acid (ILA; product of tryptophan metabolism), was observed to be the strongest immunostimulant among all the GAMs studied. Dysfunction linkage: mitochondrial dysfunction; functional impairment; cell death; cancer. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-04score 77

  FAM136A is an essential chaperone for mitochondrial membrane protein biogenesis

  Scientific focus: OXPHOS, biogenesis, metabolism, genetics. Core claim (from abstract): ABSTRACT The metabolic and signaling function of mitochondria rely on a network of chaperones within the inner membrane space (IMS) that regulate the biogenesis of nascent mitochondrial proteins. Dysfunction linkage: OXPHOS / ETC; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-29score 77

  Why this mitochondrial dysfunction preprint matters: Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved 1 H and 13 C MRS at 7T: Toward Clin

  This medrxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: dysfunction, disease context, neurodegeneration.

• biorxiv2026-08-04score 76

  A guanosine metabolism-bioenergetics intersection drives Parkinson’s disease

  Scientific focus: metabolism, neurobiology. Core claim (from abstract): We show here that the reliance on these two purine-based metabolites intersect at another PD susceptibility gene that encodes nucleoside diphosphate kinase (NDK) which converts ATP into GTP. Dysfunction linkage: mitochondrial dysfunction; functional impairment; bioenergetics; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-01score 76

  Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization

  Scientific focus: mitophagy, redox biology, metabolism. Core claim (from abstract): Here, we identify multiple sequence elements that compromise the matrix localization of the phosphatase PPTC7 to facilitate its accumulation at the outer mitochondrial membrane (OMM), where it regulates mitophagy. Dysfunction linkage: mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 76

  Loss of neurofibromin alters adult metabolism via effects during a developmental critical period

  Scientific focus: OXPHOS, redox biology, metabolism, neurobiology. Core claim (from abstract): Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). Dysfunction linkage: OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-06score 75

  Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response

  Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Among the many subtypes of Charcot–Marie–Tooth (CMT) disease, several result from mutations in genes encoding aminoacyl–tRNA synthetases, enzymes required for tRNA charging during cytoplasmic and mitochondrial translation. Dysfunction linkage: molecular/genetic defect; disease context; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-05score 75

  Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma

  Scientific focus: redox biology, metabolism, cancer, genetics. Core claim (from abstract): We recently identified a noncanonical mechanism in which RTK-containing endocytic vesicles deliver extracellular glucose to hexokinases associated with the outer mitochondrial membrane, thereby promoting cellular glucose uptake. Dysfunction linkage: functional impairment; cancer; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 75

  Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure

  Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Oxidation of ethanol by alcohol dehydrogenase (ADH) consumes nicotinamide adenine dinucleotide (NAD) while generating NADH, shifting the intracellular redox state toward a highly reduced environment that impairs mitochondrial function, limits endogenous aldehyde dehydrogenase (ALDH)-mediated acetaldehyde clearance, and promotes oxidative stress and tissue injury. Dysfunction linkage: functional impairment; oxidative stress; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 73

  A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut…

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): Background Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communication. Dysfunction linkage: functional impairment; disease context; inflammation; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 72

  Stress granule fusion is a mitochondria-coordinated process for stress adaptation

  Scientific focus: mitochondrial dynamics, structural biology. Core claim (from abstract): Here, we show that stress granule fusion is facilitated by mitochondrial dynamics and membrane potential. Dysfunction linkage: functional impairment; cell death; dynamics (fission/fusion). Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 72

  SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation

  Scientific focus: apoptosis, redox biology, metabolism, immunology. Core claim (from abstract): Building on our previous finding that SAMHD1 promotes mitochondrial membrane damage in HIV-1-infected monocytic cells, here we identify a new function for SAMHD1 in enhancing HIV-1-induced glycolysis through upregulation of hexokinase 2 (HK2). Dysfunction linkage: organelle damage; oxidative stress; reactive oxygen species; cell death. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 69

  The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface

  Scientific focus: redox biology, aging, computational. Core claim (from abstract): CHCHD10 is a mitochondrial protein genetically and pathologically linked to TDP-43 dysfunction, but the molecular basis connecting both proteins has remained unclear. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-31score 69

  Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs

  Scientific focus: immunology, structural biology, computational. Core claim (from abstract): Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs. Dysfunction linkage: functional impairment; molecular/genetic defect. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 68

  Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

  Scientific focus: therapeutics, structural biology, computational. Core claim (from abstract): We hypothesized that sequence-level adaptations evolved to balance these constraints. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-08-03score 68

  Analgesic Efficacy of Native Himalayan Shilajit as Add-On Therapy in Myofascial Pain Syndrome: An Exploratory Pilot Clinical Trial

  Scientific focus: immunology, therapeutics. Core claim (from abstract): The main outcome was the percentage of participants with more than or equal to 30% VAS reduction at Day 49. Dysfunction linkage: bioenergetics; disease context. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 67

  A single Omicron mutation reshapes ORF3a-driven host-cell remodelling

  Scientific focus: metabolism, aging, structural biology, computational. Core claim (from abstract): Here, we combine complementary imaging approaches to define ORF3a function at nanometric scale, identifying underlying mechanisms, and determining how Omicron variant rewire this activity. Dysfunction linkage: aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 66

  A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 66

  Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, aging. Core claim (from abstract): In this work, we demonstrate deep-ultraviolet (UV) microscopy as a powerful, label-free, high-resolution approach for quantifying multiscale intracellular dynamics with biomolecular specificity. Dysfunction linkage: disease context; aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 66

  A Modular Platform for Purification of Organelle-associated Mitochondria Reveals Functional Specialization at Organelle Contact Sites

  Scientific focus: mitochondrial dynamics, metabolism. Core claim (from abstract): Organelle contact sites are spatially restricted hubs that regulate mitochondrial metabolism, signaling, and dynamics, and are therefore well positioned to influence mitochondrial specialization. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 65

  Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans

  Scientific focus: redox biology, critical care, computational. Core claim (from abstract): As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 65

  Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ense…

  Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Results We systematically optimized sample preparation for untargeted LC-MS metabolomics of SECM using human serum as a reference. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-08-03score 65

  A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)

  Scientific focus: redox biology, computational. Core claim (from abstract): We are currently experiencing the largest recorded outbreak in USA history during the summer of 2026. Dysfunction linkage: disease context. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-07-31score 65

  TruBlk TM Shilajit Resin Supplementation Improves Muscle Strength, Endurance, and Exercise Recovery in Males Undertaking Resistance Train…

  Scientific focus: redox biology, metabolism, therapeutics. Core claim (from abstract): Prior controlled trials have demonstrated increases in testosterone and retention of muscular strength with purified shilajit, though large trials in resistance-trained populations have been absent. Dysfunction linkage: organelle damage. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory

  Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Decoding EGFR ligand bias through an endocytic organelle platform

  Scientific focus: metabolism, immunology. Core claim (from abstract): Here, we identify a receptor-proximal mechanism that links ligand-specific EGFR activation to distinct endocytic and biological outputs. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 64

  Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): This increase in brain size evolved alongside advanced cognitive abilities as well as an elevated energetic demand. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 63

  A p32 family RNA editing factor acts in mitochondrial ribosome biogenesis

  Scientific focus: apoptosis, biogenesis. Core claim (from abstract): Here, using genetic modifications and proteomic characterization of the immunoprecipitated assemblosome, the earliest characterized mtSSU precursor, we determined that a cap of its distinctive protrusion of hitherto unknown composition consists of a p22 homotrimer. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 63

  Mitochondrial phosphate carrier-dependence of mitochondrial calcium chelation and respiration in skeletal muscle

  Scientific focus: calcium signaling, redox biology. Core claim (from abstract): Thus, PiC, the major mitochondrial Pi transporter, is well-positioned to regulate mitochondrial Ca 2+ handling. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 62

  CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides

  Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Here, we present CPPLocPred, a hierarchical machine-learning (ML) framework that predicts CPPs and their subcellular localization. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 60

  QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data

  Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 60

  Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy

  Scientific focus: redox biology, aging, structural biology. Core claim (from abstract): Modern advances in using neural networks to learn continuous implicit representations of complex shapes present a promising solution to this problem. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 57

  Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension

  Scientific focus: redox biology, cardiovascular, computational. Core claim (from abstract): Methods: We collected 32 human RV tissue biopsies from patients with idiopathic PAH, systemic sclerosis-associated PAH (SSc-PAH), systemic sclerosis without pulmonary hypertension, with 24 nonfailing donor RVs serving as controls. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 55

  Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain

  Scientific focus: structural biology. Core claim (from abstract): Here, we report the analysis of genome-wide data for 534 individuals from the Arras Culture of Middle Iron Age northeast England (including 390 from Wetwang Slack, 100 from Pocklington, and 29 from Melton), finding evidence for communities with kinship systems structured along matrilineal lines. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-31score 55

  MitoDate: a Nextflow pipeline for molecular clock dating and phylogenetic inference using ancient mitogenomes

  Scientific focus: computational. Core claim (from abstract): In cases where complete mitochondrial genomes (mitogenomes) can be recovered from such samples, Bayesian molecular clock dating approaches are routinely used as an alternative method for estimating their age. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-30score 54

  Biogeography and cryptic diversity of the ancient centipede genus Digitipes (Scolopendromorpha) in South and Southeast Asia

  Scientific focus: mtDNA. Core claim (from abstract): In this study, we investigate the historical biogeography of the ancient centipede genus Digitipes Attems, 1930 from South and Southeast Asia. Dysfunction linkage: mtDNA. Lower priority within the current window unless the topic matches a narrow research focus.

• biorxiv2026-07-27score 53

  Why this mitochondrial dysfunction preprint matters: Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber’s Hereditary Optic Neuropath

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, mtDNA, disease context, neurodegeneration.

• biorxiv2026-08-05score 48

  A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii

  Scientific focus: metabolism, structural biology, computational. Core claim (from abstract): Yet, little is known about the makeup or function of their MCSs, leaving a gap in our understanding of how organelles communicate beyond conventional model eukaryotes. Dysfunction linkage: disease context. Lower priority within the current window unless the topic matches a narrow research focus.

• biorxiv2026-08-07score 47

  FIDDL: depth-matched negative controls distinguish genuine interspecific introgression from competitive-mapping artifact

  Scientific focus: redox biology. Core claim (from abstract): Using strains that cannot contain the ancestry being detected, we show this design generates substantial false-positive signal through two mechanisms with opposite phylogenetic-distance signatures. Dysfunction linkage: not strongly labeled in the abstract. Lower priority within the current window unless the topic matches a narrow research focus.

• biorxiv2026-07-27score 45

  Why this mitochondrial dysfunction preprint matters: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Brea

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: dysfunction, disease context, cancer.

• biorxiv2026-07-28score 43

  Mitos importance brief: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Tr

  This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, therapeutics, cancer. Dysfunction-adjacent signals: OXPHOS / ETC, cancer.

• biorxiv2026-07-29score 39

  Mitos importance brief: KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling

  This biorxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: ROS / oxidative stress.

• biorxiv2026-07-28score 39

  Mitos importance brief: Glycolytic and serine biosynthetic pathways with a novel mitochondrial location contribute to fitness in the oomycete Phytophthora

  This biorxiv preprint matters for mitochondria agents because it engages mitochondria. Dysfunction-adjacent signals: disease context.

• biorxiv2026-07-26score 39

  Mitos importance brief: A GSK3-dependent phosphorylation switch licenses BNIP3-mediated mitophagy

  This biorxiv preprint matters for mitochondria agents because it engages mitophagy. Dysfunction-adjacent signals: mitophagy.

• biorxiv2026-07-28score 35

  Mitos importance brief: Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism

  This biorxiv preprint matters for mitochondria agents because it engages mitochondria. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-08-06score 33

  Mitos importance brief: Molecular insights into ATP synthase c-ring accumulation in BMP-deficient lysosomes in Batten disease

  This biorxiv preprint matters for mitochondria agents because it engages mitochondria. Dysfunction-adjacent signals: disease context, neurodegeneration.

• biorxiv2026-07-27score 33

  Mitos importance brief: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, cancer. Dysfunction-adjacent signals: mtDNA, cancer.

• biorxiv2026-07-30score 29

  Mitos importance brief: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: cancer.

• biorxiv2026-07-29score 29

  Mitos importance brief: Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology. Dysfunction-adjacent signals: mtDNA.

• biorxiv2026-07-29score 29

  Mitos importance brief: A human cytokine response atlas to reconstruct underlying gene regulatory networks

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Dysfunction-adjacent signals: disease context.

• biorxiv2026-07-29score 29

  Mitos importance brief: Dimerization-dependent cis -autophosphorylation activates the UPR and ISR kinases

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Dysfunction-adjacent signals: ROS / oxidative stress.

• biorxiv2026-07-28score 29

  Mitos importance brief: Doxycycline Modulates Uveal-Melanoma-Associated Marker Expression in BAP1-Repressed Human Ocular Organoids

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, cancer. Dysfunction-adjacent signals: cancer.

• biorxiv2026-08-06score 25

  Mitos importance brief: Structural cell biology by mega-expansion microscopy

  This biorxiv preprint matters for mitochondria agents because it engages redox biology, aging. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-30score 25

  Mitos importance brief: Unraveling Wheat Aphid Diversity in Bangladesh Through Integrative Genetic and Morphological Approaches

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-29score 25

  Mitos importance brief: The mitoribosome-associated factor Mrx9 acts as a negative regulator of the prohibitin/m-AAA complex

  This biorxiv preprint matters for mitochondria agents because it engages mitochondria. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-29score 25

  Mitos importance brief: Transcriptional Profiling of Planarian Regeneration Habituating to Physiological Stressor Reveals Individual and Collective Dynamics

  This biorxiv preprint matters for mitochondria agents because it engages neurobiology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-28score 25

  Mitos importance brief: Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis Therapies

  This biorxiv preprint matters for mitochondria agents because it engages mitochondria. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-27score 25

  Mitos importance brief: Integrative taxonomy reveals cryptic diversity in Chilean Trichomycterinae (Siluriformes, Trichomycteridae)

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-27score 25

  Mitos importance brief: Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-26score 25

  Mitos importance brief: Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of Wh

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.