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biorxiv2026-08-14bioenergeticsOXPHOStheoryphotobiology

A theory paper: infrared photons as a Marcus-theory bias on mitochondrial electron transfer

This is a physical-framework essay, not an experiment. The authors note that built environments replaced infrared-rich daylight with narrow visible lighting, and that the solar photon-energy peak near 0.75 eV overlaps mitochondrial electron-transfer reorganization energies. In a Marcus-type picture, infrared photons could bias barrier crossing rather than donate chemical energy, and they penetrate tissue as a diffuse field. They name this “photometabolism” and offer a scaling argument that photon interception in this band tracks basal metabolic rate with body mass. No mitochondrion was illuminated in a controlled assay in the abstract.

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Signal profile (abstract-level)

bioenergetics · OXPHOS · theory · photobiology

Score 64/100BIORXIVlow confidencebioenergetics
64
Importance
50
Mito signal
25
Dysfunction
75
Evidence
30
Translational

Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.

Finding. This paper does not shine a lamp on a mitochondrion. It argues that the Sun’s photon-energy peak, near 0.75 eV, sits on the same scale as the barriers that gate mitochondrial electron transfer, and that buildings have removed those infrared photons from daily life. In Marcus language, such photons could bias whether an electron hops, not pay for ATP. The authors call the idea photometabolism and note that interception of that band might scale with body mass like basal metabolic rate. Treat every sentence as a hypothesis.

Why this paper matters

Lighting engineering optimized lumens and forgot metabolism. That cultural fact is real. Whether mitochondria care about the missing infrared is unshown. A mitochondrial desk should host the hypothesis and refuse the leap to indoor-health advice.

The useful constraint they offer is energy-scale overlap plus deep tissue penetration. The missing experiment is an action spectrum on electron-transfer kinetics.

What they actually measured

Nothing biological is measured in the abstract. Spectrum comparisons, a Marcus framing, a penetration argument, a scaling analysis.

How to read the score

Low sixties as evidence, mid sixties as a prompt. Score 64. Confidence is low.

What to do with it

If you design lighting or think about non-visual photobiology, this is a testable claim list. If you cite it as showing that LEDs harm mitochondria, you are overrunning the paper. The directional implication is only that someone should measure whether IR photons change ETC barrier crossing.

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Source preprint

Metabolism in the Solar Photon Field A physical framework for photon-assisted modulation of mitochondrial electron-transfer kinetics

10.64898/2026.08.11.744135

Fosbury RAE, Seheult R, Zimmerman S, Jeffery G.

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