CSF linoleic acid is high after aneurysmal SAH. In mice and hemoglobin-hit microglia, an LA to lysophosphatidylglycerol 16:0 to PPAR-delta path is proposed to stabilize a noncanonical mitochondrial PPAR-beta/delta, tether lipid droplets to mitochondria, and ease microglial failure. The posted abstract is truncated before the full mechanistic numbers.
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Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.
Finding. After aneurysmal subarachnoid hemorrhage, CSF linoleic acid is high. Zou, Hang, Li and colleagues argue that LA, through LPG 16:0, stabilizes a noncanonical mitochondrial PPAR-delta, tethers lipid droplets to mitochondria, and helps microglia. The posted abstract ends before the functional payload.
Score 73, confidence low. Human metabolite plus a titled mechanism the abstract does not finish. Read the PDF before you build on the tether.
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Linoleic Acid-Lyso PG Axis promoting lipid droplet–mitochondria tethering by stabilizing Noncanonically Mitochondrial PPAR β/δ to Ameliorate Microglial Dysfunction in subarachnoid hemorrhage
10.64898/2026.08.26.747434
Zou L, Hu H, Liu X, Shen J, Gao S, Ding P, Tian K, Dong X, Lu X, Liu R, Li X, Peng Z, Chen X, Hang C, Li W.
