Abt-373 and VSV push mitochondrial RNA (and mtDNA) into the cytosol through BAX/BAK and VDAC1. In A549 cells that RNA lights RIG-I, MDA5, TLR3/7/8, and PKR. The RNA carries m6A; the methylation machinery sets how long it stays cytosolic and how it binds RIG-I, which sets the inflammatory gain.
Mito.news · at a glance
mtRNA · innate immunity · apoptosis
Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.
Finding. Mitochondrial RNA can leave the organelle and look like a virus. Hu, Lu and colleagues push it out with Abt-373 or vesicular stomatitis virus, through BAX/BAK and VDAC1, mtDNA coming along. In A549 cells the RNA talks to RIG-I, MDA5, TLR3/7/8, and PKR. It is m6A-methylated. The methylation machinery decides how long it sits in the cytosol and how it binds RIG-I, which decides the innate pulse.
Score 87. Pores, PRRs, an epitranscriptomic timer. High confidence for the in-vitro path.
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The mitochondrial RNA extrusion-induced innate immunity is regulated by N6-methyladenosine machinery
10.64898/2026.08.27.747681
Hu Q, Zhang Y, Wang S, Zeng X, Wang F, Fu T, Chen Y, Lyu J, Lu M.
