Finding. Six hundred sixty-eight young-onset Indian Parkinson patients (mean motor start 39.4 years) were sequenced in GOPI-YOPD. Half have something reportable. Menon and colleagues keep pathogenic/likely-pathogenic genes (11) apart from VUS (40), enrich them, then project pathways onto people. Among those 336 carriers, mitochondrial organization is 73.5%, autophagy 67.9%, synaptic-vesicle transport 59.8%. PRKN is the most common pathogenic gene before the abstract cuts off.
Why this paper matters European PD genetics already knew Parkin and mitochondria. An Indian young-onset cohort that still lands there, with participant-level percentages, is how you stop pretending one ancestry is the disease.
Score 80. Cohort size, organelle pathway dominance, PRKN. Confidence is medium: VUS inflation, truncated results.
What to do with it If you catalog non-European PD genetics, take the 73.5% mitochondrial-organization number with the P/LP-versus-VUS split attached. Read the full PRKN table in the PDF.