Finding. Thyroid hormone can antifibrose a lung and wreck a body. Barnthaler, Rosas and colleagues try sobetirome, a THRB agonist, in the peritoneum or the airway. Bleomycin fibrosis eases. Toxicity does not show. The path is THRB to PPARGC1A, mitochondrial homeostasis restored. Alveolar type II cells stop dying. IPF fibroblasts start dying and change metabolism. Take Ppargc1a out of either cell type and the drug is gone. Human IPF tissue transcription backs up: COL1A1, COL3A1, POSTN, CTSK, CHI3L1 down.
Score 86. Mitochondrial mechanism, dual-cell PGC-1alpha requirement, human tissue. High confidence in the mouse genetics as stated.