Human iPSC proxiloids become lumenized, polarized proximal-tubule organoids in 14 days with transport and oxidative metabolic competence. They see aminoglycoside injury better than matched 2D cultures and flag adefovir mitochondrial toxicity that rodents missed. A scalable NAM for PT drugs that hit mitochondria.
Mito.news · at a glance
methods · nephrology · toxicology · OXPHOS
Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.
Finding. Biermans, Rabelink, Hochane and colleagues grow proxiloids: 14-day human iPSC tubules that lumenize, polarize, transport, and keep oxidative metabolism. They feel aminoglycosides harder than matched 2D. They see adefovir mitochondrial toxicity rodents missed.
Score 75. Human NAM, mitochondrial-toxicity catch. Medium confidence on the metabolic assay details.
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Scalable proxiloids enable human-relevant assessment of kidney proximal tubule toxicity
10.64898/2026.08.31.748260
Biermans S, van Heugten DN, Avramut MC, Verkerk RF, van Nieuwland RY, van Scheppingen RH, van den Berk L, van den Berg CW, van de Water B, Rabelink TJ, Hochane M, Spijker HS.
