Finding. Prohibitins keep a heart's carbon honest. Huo, Anderson and colleagues wipe the PHB complex out of adult cardiomyocytes. mTORC1 will not sit down. Glucose is spent on new amino acids, a Warburg-like biosynthetic turn. Mitochondrial calcium handling breaks. Autophagy fails. The ventricle dilates. Mice are gone inside 12 weeks. Block mTORC1 and only the females remodel less.
Why this paper matters DCM papers often end at 'energy failure.' This one starts at a mitochondrial scaffold and walks through a growth-kinase and a carbon-allocation error. The female-only rescue is a trial-design warning, not a footnote.
Score 91. Scaffold, mTORC1, mito-Ca2+, autophagy, sex, lethality. High confidence for the mouse phenomenology.