DIA proteomics of a CKD model with DVA, KY, and combo arms finds a cluster of mitochondrial/OXPHOS/metabolic proteins that CKD turns down and DVA turns back up, and a second cluster of immune, oxidative-stress, and cytoskeletal proteins that CKD turns up and DVA turns down. The title's mitochondrial restoration is that first cluster.
Mito.news · at a glance
nephrology · OXPHOS · therapeutics
Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.
Finding. Chronic kidney disease proteomes in Shettigar and Najar's DIA study fall into two DVA-movable piles. Cluster 1 is mitochondrial function, oxidative phosphorylation, and metabolism: down in CKD, back after DVA. Cluster 2 is immune signaling, oxidative stress, and cytoskeletal remodeling: up in CKD, down after DVA. The title names Rho GTPase on that second pile.
Score 72. Restoration-versus-suppression map. Medium confidence: unnamed chemistry, no respiration.
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Systems-level proteomic reprogramming reveals mitochondrial restoration and inhibition of Rho GTPase-mediated cytoskeletal and inflammatory signaling in CKD
10.64898/2026.09.02.748845
Shettigar R, Dagamajalu S, Kampa H, Salian D, Najar MA.
