Finding. IOMM-Lee, the workhorse Grade 3 meningioma line, is NF2-wildtype, TERT-promoter mutant, fast, clonogenic, relatively radiosensitive, and newly equipped with an mtDNA variant list and a 34-drug nanomolar hit sheet. ATM blockade makes radiation worse. It is related to other meningioma models and also distinct. Use the passport; do not pretend this is a mitochondrial-disease paper.
Why this paper matters
Bad models waste drug screens. IOMM-Lee was partly characterized. Filling exome, mtDNA, kinetics, radiation, and a clinical-compound deck makes the line safer to interpret. The TERT-124 / NF2wt combination locates it in a real genomic meningioma bin.
What they actually measured
Exome, mtDNA variants, PDT, CFE, D10, AZD-1390 radiosensitization, 349-drug screen.
How to read the score
Low sixties. Score 63.
What to do with it
If you use IOMM-Lee, read the mtDNA and TERT calls before you claim an NF2 mechanism. Pull the hit list. Measure mitochondria if you care; they did not. The directional implication is that this malignant meningioma model is now genomically and pharmacologically better pinned, mtDNA included.