Unpredictable chronic mild stress makes both sexes look depressed, then diverges: females lose regional synapses, males lose hippocampal neurons. Brain-resident lymphocytes carry the cytokine split. Females enrich gamma-delta type-2/17 and inflammasome genes; males enrich alpha-beta and NKT type-1, CXCR3, IL27RA, and IFNgamma after stress. Mitochondria are not the measured object.
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neurobiology · immunology
Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.
Finding. Chronic mild stress depresses both sexes and then parts them. Paris, Wang and colleagues see synaptic loss in females and neuron loss in male hippocampus. Brain-resident lymphocytes hold the cytokines: female gamma-delta cells look type 2/17 and inflammasome-high; male alpha-beta and NKT cells look type 1 and, after stress, make more IFNgamma.
Score 44. Immunology, not mitochondria. In the queue, so the brief says so.
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Chronic stress promotes sex-divergent Type 1, 2 and 17 responses in brain resident lymphocytes
10.64898/2026.08.31.748329
Paris S, Cao K, Park Y, Lee KJ, Zhou S, Uthayakumar D, Novelo M, Tuncer A, Qian C, Wang C.
