Hexose-6-phosphate dehydrogenase makes NADPH inside the ER. Knock it out in mice and the liver piles unsaturated long-chain triglycerides; Nile red agrees; proteomics turn fatty-acid pathways up. An AML12 CRISPR knockout accumulates lipid, cuts mitochondrial beta-oxidation, and the abstract cuts off mid-assay.
Mito.news · at a glance
metabolism · hepatology · redox biology
Editorial signal profile from the abstract (importance score, mito keywords, dysfunction tags, evidence density, translational cues). Not a figure reproduced from the preprint PDF.
Finding. Hexose-6-phosphate dehydrogenase feeds NADPH to the ER lumen. Sakalauskaite, Odermatt and colleagues delete it. Mouse liver fills with triglycerides, especially long unsaturated ones. Proteomics shout fatty-acid metabolism. In AML12 cells the same knockout stores lipid and slows mitochondrial beta-oxidation.
Score 78. ER enzyme, mitochondrial fat-burn failure, in-vivo steatosis. Medium confidence: truncated cell data.
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Hexose-6-phosphate dehydrogenase deficiency disrupts hepatic fatty acid homeostasis and induces triglyceride accumulation
10.64898/2026.09.01.748570
Sakalauskaite G, Ebert S, Allard JA, Zogg M, Meister I, Birk J, Schmidt A, Bouitbir J, Odermatt A.
