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Mitochondria importance articles
Abstract-level scientific briefs on mitochondria preprints—structured for researchers and agents. Free in the browser. Machine JSON remains available via x402 for bots.
23 of 77 articles · updated 2026-08-08T16:01Z
- biorxiv2026-08-04score 93mitophagyOXPHOSredox biology
The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
Scientific focus: mitophagy, OXPHOS, redox biology, metabolism. Core claim (from abstract): Melittin significantly inhibited the migration and invasion of U14 cervical cancer cells and increased cell death. Dysfunction linkage: oxidative stress; reactive oxygen species; cell death; mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
- biorxiv2026-07-31score 83redox biologymetabolismtherapeutics
Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)
Scientific focus: redox biology, metabolism, therapeutics, computational. Core claim (from abstract): Metabolic perturbation, mitochondrial dysfunction, and oxidative stress are key contributors to FSHD pathology. Dysfunction linkage: mitochondrial dysfunction; oxidative stress; reactive oxygen species; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)
- biorxiv2026-07-31score 82cardiovascularstructural biologycomputational
The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy
Scientific focus: cardiovascular, structural biology, computational. Core claim (from abstract): Variants in SMYD1, a striated muscle-specific lysine methyltransferase critical for cardiac development and mitochondrial function, have only recently been linked to human cardiomyopathy. Dysfunction linkage: mitochondrial dysfunction; functional impairment; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy.
- biorxiv2026-08-07score 78redox biologyneurobiologyimmunology
Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
- biorxiv2026-07-31score 76OXPHOSredox biologymetabolism
Loss of neurofibromin alters adult metabolism via effects during a developmental critical period
Scientific focus: OXPHOS, redox biology, metabolism, neurobiology. Core claim (from abstract): Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). Dysfunction linkage: OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Loss of neurofibromin alters adult metabolism via effects during a developmental critical period
- biorxiv2026-08-06score 75redox biologytherapeuticscomputational
Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Among the many subtypes of Charcot–Marie–Tooth (CMT) disease, several result from mutations in genes encoding aminoacyl–tRNA synthetases, enzymes required for tRNA charging during cytoplasmic and mitochondrial translation. Dysfunction linkage: molecular/genetic defect; disease context; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
- biorxiv2026-07-31score 75redox biologymetabolismcomputational
Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure
Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Oxidation of ethanol by alcohol dehydrogenase (ADH) consumes nicotinamide adenine dinucleotide (NAD) while generating NADH, shifting the intracellular redox state toward a highly reduced environment that impairs mitochondrial function, limits endogenous aldehyde dehydrogenase (ALDH)-mediated acetaldehyde clearance, and promotes oxidative stress and tissue injury. Dysfunction linkage: functional impairment; oxidative stress; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure
- biorxiv2026-07-31score 73redox biologymetabolismneurobiology
A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut…
Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): Background Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communication. Dysfunction linkage: functional impairment; disease context; inflammation; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut-Brain, and Gut-Liver Signaling
- biorxiv2026-08-06score 69redox biologyagingcomputational
The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface
Scientific focus: redox biology, aging, computational. Core claim (from abstract): CHCHD10 is a mitochondrial protein genetically and pathologically linked to TDP-43 dysfunction, but the molecular basis connecting both proteins has remained unclear. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. Moderate priority: useful for specialists in the listed topics.
Source preprint: The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface
- biorxiv2026-07-31score 69immunologystructural biologycomputational
Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs
Scientific focus: immunology, structural biology, computational. Core claim (from abstract): Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs. Dysfunction linkage: functional impairment; molecular/genetic defect. Moderate priority: useful for specialists in the listed topics.
Source preprint: Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs
- biorxiv2026-08-07score 68therapeuticsstructural biologycomputational
Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution
Scientific focus: therapeutics, structural biology, computational. Core claim (from abstract): We hypothesized that sequence-level adaptations evolved to balance these constraints. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution
- biorxiv2026-08-04score 67metabolismagingstructural biology
A single Omicron mutation reshapes ORF3a-driven host-cell remodelling
Scientific focus: metabolism, aging, structural biology, computational. Core claim (from abstract): Here, we combine complementary imaging approaches to define ORF3a function at nanometric scale, identifying underlying mechanisms, and determining how Omicron variant rewire this activity. Dysfunction linkage: aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A single Omicron mutation reshapes ORF3a-driven host-cell remodelling
- biorxiv2026-08-06score 66mitochondrial dynamicsredox biologymetabolism
A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis
Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis: Conditional Emergence of Coordinated Disruption under the Gate Condition
- biorxiv2026-08-06score 65redox biologycritical carecomputational
Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans
Scientific focus: redox biology, critical care, computational. Core claim (from abstract): As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans
- biorxiv2026-08-04score 65redox biologymetabolismcomputational
Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ense…
Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Results We systematically optimized sample preparation for untargeted LC-MS metabolomics of SECM using human serum as a reference. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ensemble Machine Learning
- medrxiv2026-08-03score 65redox biologycomputational
A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)
Scientific focus: redox biology, computational. Core claim (from abstract): We are currently experiencing the largest recorded outbreak in USA history during the summer of 2026. Dysfunction linkage: disease context. Moderate priority: useful for specialists in the listed topics.
Source preprint: A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)
- biorxiv2026-08-04score 64redox biologyimmunologyaging
Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory
Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory
- biorxiv2026-08-01score 64redox biologymetabolismneurobiology
Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk
Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): This increase in brain size evolved alongside advanced cognitive abilities as well as an elevated energetic demand. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk
- biorxiv2026-08-01score 62redox biologytherapeuticscomputational
CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides
Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Here, we present CPPLocPred, a hierarchical machine-learning (ML) framework that predicts CPPs and their subcellular localization. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides
- biorxiv2026-08-07score 60redox biologyagingstructural biology
QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data
Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data
- biorxiv2026-08-01score 57redox biologycardiovascularcomputational
Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension
Scientific focus: redox biology, cardiovascular, computational. Core claim (from abstract): Methods: We collected 32 human RV tissue biopsies from patients with idiopathic PAH, systemic sclerosis-associated PAH (SSc-PAH), systemic sclerosis without pulmonary hypertension, with 24 nonfailing donor RVs serving as controls. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension
- biorxiv2026-07-31score 55computational
MitoDate: a Nextflow pipeline for molecular clock dating and phylogenetic inference using ancient mitogenomes
Scientific focus: computational. Core claim (from abstract): In cases where complete mitochondrial genomes (mitogenomes) can be recovered from such samples, Bayesian molecular clock dating approaches are routinely used as an alternative method for estimating their age. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: MitoDate: a Nextflow pipeline for molecular clock dating and phylogenetic inference using ancient mitogenomes
- biorxiv2026-08-05score 48metabolismstructural biologycomputational
A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii
Scientific focus: metabolism, structural biology, computational. Core claim (from abstract): Yet, little is known about the makeup or function of their MCSs, leaving a gap in our understanding of how organelles communicate beyond conventional model eukaryotes. Dysfunction linkage: disease context. Lower priority within the current window unless the topic matches a narrow research focus.
Source preprint: A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii