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Mitochondria importance articles
Abstract-level scientific briefs on mitochondria preprints—structured for researchers and agents. Free in the browser. Machine JSON remains available via x402 for bots.
47 of 77 articles · updated 2026-08-08T16:01Z
- biorxiv2026-07-29score 95OXPHOSneurobiologytherapeutics
Why this mitochondrial dysfunction preprint matters: Ringer Loss in Uncovers Mitochondrial Complex I Deficits Characteristic of Human Parkinson′s Disease
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, OXPHOS / ETC, disease context, neurodegeneration.
Source preprint: Ringer Loss in Drosophila Uncovers Mitochondrial Complex I Deficits Characteristic of Human Parkinson’s Disease
- biorxiv2026-07-28score 95neurobiologyredox biology
Why this mitochondrial dysfunction preprint matters: Corilagin attenuates high glucose-induced neurotoxicity and mitochondrial dysfunction through restoration of the AMPK-SI
This biorxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, neurodegeneration.
Source preprint: Corilagin attenuates high glucose-induced neurotoxicity and mitochondrial dysfunction through restoration of the AMPK-SIRT1-PGC1α-TFAM signalling axis
- biorxiv2026-08-04score 94OXPHOSmitochondrial dynamicsredox biology
Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptati…
Scientific focus: OXPHOS, mitochondrial dynamics, redox biology, biogenesis. Core claim (from abstract): In the present study, we examined the molecular mechanisms underlying nanoparticle-induced mitochondrial stress response and immunotoxicity using human peripheral blood mononuclear cells exposed to UFPM, BC, and PS-NPs under similar experimental conditions. Dysfunction linkage: mitochondrial dysfunction; organelle damage; oxidative stress; OXPHOS / ETC. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptation as a Conserved Mechanism of Immunotoxicity
- biorxiv2026-08-04score 93OXPHOSredox biologyneurobiology
Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction
Scientific focus: OXPHOS, redox biology, neurobiology, structural biology. Core claim (from abstract): Here we show that elevated intracellular cholesterol in murine astrocytes expressing the Alzheimer’s disease risk variant APOE4 disrupts the inner mitochondrial membrane, manifesting as sparse, truncated cristae alongside an excess of cristae junction complexes. Dysfunction linkage: mitochondrial dysfunction; cell death; OXPHOS / ETC; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction
- biorxiv2026-08-04score 93mitophagyOXPHOSredox biology
The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
Scientific focus: mitophagy, OXPHOS, redox biology, metabolism. Core claim (from abstract): Melittin significantly inhibited the migration and invasion of U14 cervical cancer cells and increased cell death. Dysfunction linkage: oxidative stress; reactive oxygen species; cell death; mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
- biorxiv2026-08-03score 93redox biologymetabolismimmunology
Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…
Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation
- medrxiv2026-07-29score 91therapeuticsredox biology
Why this mitochondrial dysfunction preprint matters: Novel in vivo measurement of muscle total carnitine concentration reveals potential mechanism linking mitochondrial dysf
This medrxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Dysfunction-adjacent signals: dysfunction, disease context.
Source preprint: Novel in vivo measurement of muscle total carnitine concentration reveals potential mechanism linking mitochondrial dysfunction and lipid accumulation
- medrxiv2026-08-03score 83mtDNAOXPHOSredox biology
Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease
Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease
- biorxiv2026-07-31score 83redox biologymetabolismtherapeutics
Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)
Scientific focus: redox biology, metabolism, therapeutics, computational. Core claim (from abstract): Metabolic perturbation, mitochondrial dysfunction, and oxidative stress are key contributors to FSHD pathology. Dysfunction linkage: mitochondrial dysfunction; oxidative stress; reactive oxygen species; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)
- biorxiv2026-08-03score 82mitochondrial dynamicsredox biologymetabolism
Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis
Scientific focus: mitochondrial dynamics, redox biology, metabolism, immunology. Core claim (from abstract): In pancreas tissue from donors across the natural history of T1D, we utilized an in-situ, whole - islet phenotypical and transcriptomic approach to unravel novel targets in the glucose-stimulus coupled secretion pathway that are similarly impaired in T-cell infiltrated and non-infiltrated islets. Dysfunction linkage: mitochondrial dysfunction; functional impairment; bioenergetics; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis
- medrxiv2026-07-30score 81mtDNAredox biologyaging
Why this mitochondrial dysfunction preprint matters: Data-Driven Biological Subtypes of Parkinson ′ s Disease
This medrxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, aging. Dysfunction-adjacent signals: dysfunction, mtDNA, disease context, neurodegeneration.
Source preprint: Data-Driven Biological Subtypes of Parkinson’s Disease
- biorxiv2026-08-07score 78redox biologyneurobiologyimmunology
Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
- medrxiv2026-07-29score 77neurobiologyredox biology
Why this mitochondrial dysfunction preprint matters: Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved 1 H and 13 C MRS at 7T: Toward Clin
This medrxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: dysfunction, disease context, neurodegeneration.
Source preprint: Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved 1 H and 13 C MRS at 7T: Toward Clinical Translation
- biorxiv2026-08-01score 76mitophagyredox biologymetabolism
Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization
Scientific focus: mitophagy, redox biology, metabolism. Core claim (from abstract): Here, we identify multiple sequence elements that compromise the matrix localization of the phosphatase PPTC7 to facilitate its accumulation at the outer mitochondrial membrane (OMM), where it regulates mitophagy. Dysfunction linkage: mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization
- biorxiv2026-07-31score 76OXPHOSredox biologymetabolism
Loss of neurofibromin alters adult metabolism via effects during a developmental critical period
Scientific focus: OXPHOS, redox biology, metabolism, neurobiology. Core claim (from abstract): Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). Dysfunction linkage: OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Loss of neurofibromin alters adult metabolism via effects during a developmental critical period
- biorxiv2026-08-06score 75redox biologytherapeuticscomputational
Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Among the many subtypes of Charcot–Marie–Tooth (CMT) disease, several result from mutations in genes encoding aminoacyl–tRNA synthetases, enzymes required for tRNA charging during cytoplasmic and mitochondrial translation. Dysfunction linkage: molecular/genetic defect; disease context; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
- biorxiv2026-08-05score 75redox biologymetabolismcancer
Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma
Scientific focus: redox biology, metabolism, cancer, genetics. Core claim (from abstract): We recently identified a noncanonical mechanism in which RTK-containing endocytic vesicles deliver extracellular glucose to hexokinases associated with the outer mitochondrial membrane, thereby promoting cellular glucose uptake. Dysfunction linkage: functional impairment; cancer; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma
- biorxiv2026-07-31score 75redox biologymetabolismcomputational
Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure
Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Oxidation of ethanol by alcohol dehydrogenase (ADH) consumes nicotinamide adenine dinucleotide (NAD) while generating NADH, shifting the intracellular redox state toward a highly reduced environment that impairs mitochondrial function, limits endogenous aldehyde dehydrogenase (ALDH)-mediated acetaldehyde clearance, and promotes oxidative stress and tissue injury. Dysfunction linkage: functional impairment; oxidative stress; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure
- biorxiv2026-07-31score 73redox biologymetabolismneurobiology
A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut…
Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): Background Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communication. Dysfunction linkage: functional impairment; disease context; inflammation; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut-Brain, and Gut-Liver Signaling
- biorxiv2026-08-04score 72apoptosisredox biologymetabolism
SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation
Scientific focus: apoptosis, redox biology, metabolism, immunology. Core claim (from abstract): Building on our previous finding that SAMHD1 promotes mitochondrial membrane damage in HIV-1-infected monocytic cells, here we identify a new function for SAMHD1 in enhancing HIV-1-induced glycolysis through upregulation of hexokinase 2 (HK2). Dysfunction linkage: organelle damage; oxidative stress; reactive oxygen species; cell death. Moderate priority: useful for specialists in the listed topics.
Source preprint: SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation
- biorxiv2026-08-06score 69redox biologyagingcomputational
The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface
Scientific focus: redox biology, aging, computational. Core claim (from abstract): CHCHD10 is a mitochondrial protein genetically and pathologically linked to TDP-43 dysfunction, but the molecular basis connecting both proteins has remained unclear. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. Moderate priority: useful for specialists in the listed topics.
Source preprint: The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface
- biorxiv2026-08-06score 66mitochondrial dynamicsredox biologymetabolism
A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis
Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis: Conditional Emergence of Coordinated Disruption under the Gate Condition
- biorxiv2026-08-04score 66mitochondrial dynamicsredox biologymetabolism
Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics
Scientific focus: mitochondrial dynamics, redox biology, metabolism, aging. Core claim (from abstract): In this work, we demonstrate deep-ultraviolet (UV) microscopy as a powerful, label-free, high-resolution approach for quantifying multiscale intracellular dynamics with biomolecular specificity. Dysfunction linkage: disease context; aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics
- biorxiv2026-08-06score 65redox biologycritical carecomputational
Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans
Scientific focus: redox biology, critical care, computational. Core claim (from abstract): As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans
- biorxiv2026-08-04score 65redox biologymetabolismcomputational
Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ense…
Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Results We systematically optimized sample preparation for untargeted LC-MS metabolomics of SECM using human serum as a reference. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ensemble Machine Learning
- medrxiv2026-08-03score 65redox biologycomputational
A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)
Scientific focus: redox biology, computational. Core claim (from abstract): We are currently experiencing the largest recorded outbreak in USA history during the summer of 2026. Dysfunction linkage: disease context. Moderate priority: useful for specialists in the listed topics.
Source preprint: A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)
- medrxiv2026-07-31score 65redox biologymetabolismtherapeutics
TruBlk TM Shilajit Resin Supplementation Improves Muscle Strength, Endurance, and Exercise Recovery in Males Undertaking Resistance Train…
Scientific focus: redox biology, metabolism, therapeutics. Core claim (from abstract): Prior controlled trials have demonstrated increases in testosterone and retention of muscular strength with purified shilajit, though large trials in resistance-trained populations have been absent. Dysfunction linkage: organelle damage. Moderate priority: useful for specialists in the listed topics.
Source preprint: TruBlk™ Shilajit Resin Supplementation Improves Muscle Strength, Endurance, and Exercise Recovery in Males Undertaking Resistance Training: A Randomised, Double-Blind, Placebo-Controlled, Multicenter Trial
- biorxiv2026-08-04score 64redox biologyimmunologyaging
Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory
Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory
- biorxiv2026-08-01score 64redox biologymetabolismneurobiology
Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk
Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): This increase in brain size evolved alongside advanced cognitive abilities as well as an elevated energetic demand. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk
- biorxiv2026-08-04score 63calcium signalingredox biology
Mitochondrial phosphate carrier-dependence of mitochondrial calcium chelation and respiration in skeletal muscle
Scientific focus: calcium signaling, redox biology. Core claim (from abstract): Thus, PiC, the major mitochondrial Pi transporter, is well-positioned to regulate mitochondrial Ca 2+ handling. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Mitochondrial phosphate carrier-dependence of mitochondrial calcium chelation and respiration in skeletal muscle
- biorxiv2026-08-01score 62redox biologytherapeuticscomputational
CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides
Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Here, we present CPPLocPred, a hierarchical machine-learning (ML) framework that predicts CPPs and their subcellular localization. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides
- biorxiv2026-08-07score 60redox biologyagingstructural biology
QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data
Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data
- biorxiv2026-08-04score 60redox biologyagingstructural biology
Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy
Scientific focus: redox biology, aging, structural biology. Core claim (from abstract): Modern advances in using neural networks to learn continuous implicit representations of complex shapes present a promising solution to this problem. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy
- biorxiv2026-08-01score 57redox biologycardiovascularcomputational
Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension
Scientific focus: redox biology, cardiovascular, computational. Core claim (from abstract): Methods: We collected 32 human RV tissue biopsies from patients with idiopathic PAH, systemic sclerosis-associated PAH (SSc-PAH), systemic sclerosis without pulmonary hypertension, with 24 nonfailing donor RVs serving as controls. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension
- biorxiv2026-08-07score 47redox biology
FIDDL: depth-matched negative controls distinguish genuine interspecific introgression from competitive-mapping artifact
Scientific focus: redox biology. Core claim (from abstract): Using strains that cannot contain the ancestry being detected, we show this design generates substantial false-positive signal through two mechanisms with opposite phylogenetic-distance signatures. Dysfunction linkage: not strongly labeled in the abstract. Lower priority within the current window unless the topic matches a narrow research focus.
Source preprint: FIDDL: depth-matched negative controls distinguish genuine interspecific introgression from competitive-mapping artifact
- biorxiv2026-07-27score 45therapeuticsredox biologycancer
Why this mitochondrial dysfunction preprint matters: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Brea
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: dysfunction, disease context, cancer.
Source preprint: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast Cancer
- biorxiv2026-07-29score 39neurobiologyredox biology
Mitos importance brief: KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling
This biorxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: ROS / oxidative stress.
Source preprint: KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling
- biorxiv2026-07-27score 33mtDNAredox biologycancer
Mitos importance brief: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)
This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, cancer. Dysfunction-adjacent signals: mtDNA, cancer.
Source preprint: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)
- biorxiv2026-07-30score 29therapeuticsredox biologycancer
Mitos importance brief: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: cancer.
Source preprint: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation
- biorxiv2026-07-29score 29mtDNAredox biology
Mitos importance brief: Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity
This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology. Dysfunction-adjacent signals: mtDNA.
Source preprint: Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity
- biorxiv2026-07-29score 29redox biology
Mitos importance brief: A human cytokine response atlas to reconstruct underlying gene regulatory networks
This biorxiv preprint matters for mitochondria agents because it engages redox biology. Dysfunction-adjacent signals: disease context.
Source preprint: A human cytokine response atlas to reconstruct underlying gene regulatory networks
- biorxiv2026-07-29score 29redox biology
Mitos importance brief: Dimerization-dependent cis -autophosphorylation activates the UPR and ISR kinases
This biorxiv preprint matters for mitochondria agents because it engages redox biology. Dysfunction-adjacent signals: ROS / oxidative stress.
Source preprint: Dimerization-dependent cis -autophosphorylation activates the UPR and ISR kinases
- biorxiv2026-08-06score 25redox biologyaging
Mitos importance brief: Structural cell biology by mega-expansion microscopy
This biorxiv preprint matters for mitochondria agents because it engages redox biology, aging. Framing is largely mechanistic rather than explicit pathology.
Source preprint: Structural cell biology by mega-expansion microscopy
- biorxiv2026-07-30score 25redox biology
Mitos importance brief: Unraveling Wheat Aphid Diversity in Bangladesh Through Integrative Genetic and Morphological Approaches
This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.
Source preprint: Unraveling Wheat Aphid Diversity in Bangladesh Through Integrative Genetic and Morphological Approaches
- biorxiv2026-07-27score 25redox biology
Mitos importance brief: Integrative taxonomy reveals cryptic diversity in Chilean Trichomycterinae (Siluriformes, Trichomycteridae)
This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.
Source preprint: Integrative taxonomy reveals cryptic diversity in Chilean Trichomycterinae (Siluriformes, Trichomycteridae)
- biorxiv2026-07-27score 25therapeuticsredox biology
Mitos importance brief: Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Framing is largely mechanistic rather than explicit pathology.
Source preprint: Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis
- biorxiv2026-07-26score 25redox biology
Mitos importance brief: Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of Wh
This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.
Source preprint: Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue