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Mitochondria importance articles
Abstract-level scientific briefs on mitochondria preprints—structured for researchers and agents. Free in the browser. Machine JSON remains available via x402 for bots.
23 of 77 articles · updated 2026-08-08T16:01Z
- biorxiv2026-07-29score 95OXPHOSneurobiologytherapeutics
Why this mitochondrial dysfunction preprint matters: Ringer Loss in Uncovers Mitochondrial Complex I Deficits Characteristic of Human Parkinson′s Disease
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, OXPHOS / ETC, disease context, neurodegeneration.
Source preprint: Ringer Loss in Drosophila Uncovers Mitochondrial Complex I Deficits Characteristic of Human Parkinson’s Disease
- biorxiv2026-08-04score 93mitophagyOXPHOSredox biology
The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
Scientific focus: mitophagy, OXPHOS, redox biology, metabolism. Core claim (from abstract): Melittin significantly inhibited the migration and invasion of U14 cervical cancer cells and increased cell death. Dysfunction linkage: oxidative stress; reactive oxygen species; cell death; mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
- biorxiv2026-08-03score 93redox biologymetabolismimmunology
Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…
Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation
- medrxiv2026-07-29score 91therapeuticsredox biology
Why this mitochondrial dysfunction preprint matters: Novel in vivo measurement of muscle total carnitine concentration reveals potential mechanism linking mitochondrial dysf
This medrxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Dysfunction-adjacent signals: dysfunction, disease context.
Source preprint: Novel in vivo measurement of muscle total carnitine concentration reveals potential mechanism linking mitochondrial dysfunction and lipid accumulation
- medrxiv2026-08-06score 86OXPHOSmetabolismtherapeutics
GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype
Scientific focus: OXPHOS, metabolism, therapeutics, structural biology. Core claim (from abstract): Objectives To characterize the hepatic histological, ultrastructural, and molecular phenotype of GRO at bariatric surgery, determine its recovery following surgery, and identify preoperative hepatic biomarkers associated with postoperative weight loss. Dysfunction linkage: mitochondrial dysfunction; OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype
- biorxiv2026-07-31score 83redox biologymetabolismtherapeutics
Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)
Scientific focus: redox biology, metabolism, therapeutics, computational. Core claim (from abstract): Metabolic perturbation, mitochondrial dysfunction, and oxidative stress are key contributors to FSHD pathology. Dysfunction linkage: mitochondrial dysfunction; oxidative stress; reactive oxygen species; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)
- biorxiv2026-07-28score 83therapeuticsaging
Why this mitochondrial dysfunction preprint matters: Protein Phosphatase 2A Activation Attenuates Acute Myocardial Injury in Takotsubo Syndrome by Modulating Ferroptosis and
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, aging. Dysfunction-adjacent signals: dysfunction, disease context.
Source preprint: Protein Phosphatase 2A Activation Attenuates Acute Myocardial Injury in Takotsubo Syndrome by Modulating Ferroptosis and Mitochondrial Injury in Cardiomyocytes
- biorxiv2026-07-25score 83neurobiologytherapeutics
Why this mitochondrial dysfunction preprint matters: Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in
This biorxiv preprint matters for mitochondria agents because it engages neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, disease context.
Source preprint: Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in primary neuronal cultures
- biorxiv2026-08-07score 78redox biologyneurobiologyimmunology
Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration
- biorxiv2026-08-04score 78apoptosismetabolismimmunology
Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma
Scientific focus: apoptosis, metabolism, immunology, cancer. Core claim (from abstract): Here we report that peripheral CD8⁺ T lymphocytes in osteosarcoma patients are less frequent in circulation, hypo-producers of effector cytokines (IFN-γ and TNF-α), and have compromised metabolic fitness․ We characterized and investigated the effect of a panel of microbiota-derived GAMs on CD8⁺ T lymphocytes, confirming their immunomodulatory role with respect to CD8⁺ T lymphocytes activation, cellular metabolism and effector functions․ Indole-3-lactic acid (ILA; product of tryptophan metabolism), was observed to be the strongest immunostimulant among all the GAMs studied. Dysfunction linkage: mitochondrial dysfunction; functional impairment; cell death; cancer. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma
- biorxiv2026-08-06score 75redox biologytherapeuticscomputational
Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Among the many subtypes of Charcot–Marie–Tooth (CMT) disease, several result from mutations in genes encoding aminoacyl–tRNA synthetases, enzymes required for tRNA charging during cytoplasmic and mitochondrial translation. Dysfunction linkage: molecular/genetic defect; disease context; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response
- biorxiv2026-08-05score 75redox biologymetabolismcancer
Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma
Scientific focus: redox biology, metabolism, cancer, genetics. Core claim (from abstract): We recently identified a noncanonical mechanism in which RTK-containing endocytic vesicles deliver extracellular glucose to hexokinases associated with the outer mitochondrial membrane, thereby promoting cellular glucose uptake. Dysfunction linkage: functional impairment; cancer; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma
- biorxiv2026-08-07score 68therapeuticsstructural biologycomputational
Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution
Scientific focus: therapeutics, structural biology, computational. Core claim (from abstract): We hypothesized that sequence-level adaptations evolved to balance these constraints. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution
- medrxiv2026-08-03score 68immunologytherapeutics
Analgesic Efficacy of Native Himalayan Shilajit as Add-On Therapy in Myofascial Pain Syndrome: An Exploratory Pilot Clinical Trial
Scientific focus: immunology, therapeutics. Core claim (from abstract): The main outcome was the percentage of participants with more than or equal to 30% VAS reduction at Day 49. Dysfunction linkage: bioenergetics; disease context. Moderate priority: useful for specialists in the listed topics.
Source preprint: Analgesic Efficacy of Native Himalayan Shilajit as Add-On Therapy in Myofascial Pain Syndrome: An Exploratory Pilot Clinical Trial
- biorxiv2026-08-06score 66mitochondrial dynamicsredox biologymetabolism
A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis
Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis: Conditional Emergence of Coordinated Disruption under the Gate Condition
- medrxiv2026-07-31score 65redox biologymetabolismtherapeutics
TruBlk TM Shilajit Resin Supplementation Improves Muscle Strength, Endurance, and Exercise Recovery in Males Undertaking Resistance Train…
Scientific focus: redox biology, metabolism, therapeutics. Core claim (from abstract): Prior controlled trials have demonstrated increases in testosterone and retention of muscular strength with purified shilajit, though large trials in resistance-trained populations have been absent. Dysfunction linkage: organelle damage. Moderate priority: useful for specialists in the listed topics.
Source preprint: TruBlk™ Shilajit Resin Supplementation Improves Muscle Strength, Endurance, and Exercise Recovery in Males Undertaking Resistance Training: A Randomised, Double-Blind, Placebo-Controlled, Multicenter Trial
- biorxiv2026-08-01score 62redox biologytherapeuticscomputational
CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides
Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Here, we present CPPLocPred, a hierarchical machine-learning (ML) framework that predicts CPPs and their subcellular localization. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides
- biorxiv2026-07-27score 53mtDNAneurobiologytherapeutics
Why this mitochondrial dysfunction preprint matters: Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber’s Hereditary Optic Neuropath
This biorxiv preprint matters for mitochondria agents because it engages mtDNA, neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, mtDNA, disease context, neurodegeneration.
Source preprint: Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber’s Hereditary Optic Neuropathy
- biorxiv2026-07-27score 45therapeuticsredox biologycancer
Why this mitochondrial dysfunction preprint matters: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Brea
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: dysfunction, disease context, cancer.
Source preprint: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast Cancer
- biorxiv2026-07-28score 43OXPHOStherapeuticscancer
Mitos importance brief: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Tr
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, therapeutics, cancer. Dysfunction-adjacent signals: OXPHOS / ETC, cancer.
Source preprint: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5
- biorxiv2026-07-30score 29therapeuticsredox biologycancer
Mitos importance brief: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: cancer.
Source preprint: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation
- biorxiv2026-07-28score 29therapeuticscancer
Mitos importance brief: Doxycycline Modulates Uveal-Melanoma-Associated Marker Expression in BAP1-Repressed Human Ocular Organoids
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, cancer. Dysfunction-adjacent signals: cancer.
Source preprint: Doxycycline Modulates Uveal-Melanoma-Associated Marker Expression in BAP1-Repressed Human Ocular Organoids
- biorxiv2026-07-27score 25therapeuticsredox biology
Mitos importance brief: Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Framing is largely mechanistic rather than explicit pathology.
Source preprint: Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis