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Mitochondria importance articles
Abstract-level scientific briefs on mitochondria preprints—structured for researchers and agents. Free in the browser. Machine JSON remains available via x402 for bots.
10 of 77 articles · updated 2026-08-08T16:01Z
- biorxiv2026-07-29score 95OXPHOSneurobiologytherapeutics
Why this mitochondrial dysfunction preprint matters: Ringer Loss in Uncovers Mitochondrial Complex I Deficits Characteristic of Human Parkinson′s Disease
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, OXPHOS / ETC, disease context, neurodegeneration.
Source preprint: Ringer Loss in Drosophila Uncovers Mitochondrial Complex I Deficits Characteristic of Human Parkinson’s Disease
- biorxiv2026-07-27score 95OXPHOS
Why this mitochondrial dysfunction preprint matters: Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondria
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS. Dysfunction-adjacent signals: dysfunction, OXPHOS / ETC, disease context.
Source preprint: Bioenergetic profiling of fresh human kidney tissue reveals compensatory metabolic adaptation and intrinsic mitochondrial dysfunction in diabetes
- biorxiv2026-08-04score 94OXPHOSmitochondrial dynamicsredox biology
Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptati…
Scientific focus: OXPHOS, mitochondrial dynamics, redox biology, biogenesis. Core claim (from abstract): In the present study, we examined the molecular mechanisms underlying nanoparticle-induced mitochondrial stress response and immunotoxicity using human peripheral blood mononuclear cells exposed to UFPM, BC, and PS-NPs under similar experimental conditions. Dysfunction linkage: mitochondrial dysfunction; organelle damage; oxidative stress; OXPHOS / ETC. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Comparative Analysis of Ultrafine Particulate Matter, Black Carbon, and Polystyrene Nanoplastics Identifies Mitochondrial Stress Adaptation as a Conserved Mechanism of Immunotoxicity
- biorxiv2026-08-04score 93OXPHOSredox biologyneurobiology
Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction
Scientific focus: OXPHOS, redox biology, neurobiology, structural biology. Core claim (from abstract): Here we show that elevated intracellular cholesterol in murine astrocytes expressing the Alzheimer’s disease risk variant APOE4 disrupts the inner mitochondrial membrane, manifesting as sparse, truncated cristae alongside an excess of cristae junction complexes. Dysfunction linkage: mitochondrial dysfunction; cell death; OXPHOS / ETC; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction
- biorxiv2026-08-04score 93mitophagyOXPHOSredox biology
The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
Scientific focus: mitophagy, OXPHOS, redox biology, metabolism. Core claim (from abstract): Melittin significantly inhibited the migration and invasion of U14 cervical cancer cells and increased cell death. Dysfunction linkage: oxidative stress; reactive oxygen species; cell death; mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
- medrxiv2026-08-06score 86OXPHOSmetabolismtherapeutics
GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype
Scientific focus: OXPHOS, metabolism, therapeutics, structural biology. Core claim (from abstract): Objectives To characterize the hepatic histological, ultrastructural, and molecular phenotype of GRO at bariatric surgery, determine its recovery following surgery, and identify preoperative hepatic biomarkers associated with postoperative weight loss. Dysfunction linkage: mitochondrial dysfunction; OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype
- medrxiv2026-08-03score 83mtDNAOXPHOSredox biology
Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease
Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease
- biorxiv2026-08-04score 77OXPHOSbiogenesismetabolism
FAM136A is an essential chaperone for mitochondrial membrane protein biogenesis
Scientific focus: OXPHOS, biogenesis, metabolism, genetics. Core claim (from abstract): ABSTRACT The metabolic and signaling function of mitochondria rely on a network of chaperones within the inner membrane space (IMS) that regulate the biogenesis of nascent mitochondrial proteins. Dysfunction linkage: OXPHOS / ETC; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: FAM136A is an essential chaperone for mitochondrial membrane protein biogenesis
- biorxiv2026-07-31score 76OXPHOSredox biologymetabolism
Loss of neurofibromin alters adult metabolism via effects during a developmental critical period
Scientific focus: OXPHOS, redox biology, metabolism, neurobiology. Core claim (from abstract): Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). Dysfunction linkage: OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Loss of neurofibromin alters adult metabolism via effects during a developmental critical period
- biorxiv2026-07-28score 43OXPHOStherapeuticscancer
Mitos importance brief: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Tr
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, therapeutics, cancer. Dysfunction-adjacent signals: OXPHOS / ETC, cancer.
Source preprint: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5