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Mitochondria importance articles
Abstract-level scientific briefs on mitochondria preprints—structured for researchers and agents. Free in the browser. Machine JSON remains available via x402 for bots.
10 of 77 articles · updated 2026-08-08T16:01Z
- biorxiv2026-08-04score 93mitophagyOXPHOSredox biology
The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
Scientific focus: mitophagy, OXPHOS, redox biology, metabolism. Core claim (from abstract): Melittin significantly inhibited the migration and invasion of U14 cervical cancer cells and increased cell death. Dysfunction linkage: oxidative stress; reactive oxygen species; cell death; mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The effect of melittin intervention on murine cervical cancer cells: An in-depth proteomics investigation
- biorxiv2026-08-03score 93redox biologymetabolismimmunology
Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…
Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation
- biorxiv2026-08-04score 78apoptosismetabolismimmunology
Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma
Scientific focus: apoptosis, metabolism, immunology, cancer. Core claim (from abstract): Here we report that peripheral CD8⁺ T lymphocytes in osteosarcoma patients are less frequent in circulation, hypo-producers of effector cytokines (IFN-γ and TNF-α), and have compromised metabolic fitness․ We characterized and investigated the effect of a panel of microbiota-derived GAMs on CD8⁺ T lymphocytes, confirming their immunomodulatory role with respect to CD8⁺ T lymphocytes activation, cellular metabolism and effector functions․ Indole-3-lactic acid (ILA; product of tryptophan metabolism), was observed to be the strongest immunostimulant among all the GAMs studied. Dysfunction linkage: mitochondrial dysfunction; functional impairment; cell death; cancer. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma
- biorxiv2026-08-05score 75redox biologymetabolismcancer
Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma
Scientific focus: redox biology, metabolism, cancer, genetics. Core claim (from abstract): We recently identified a noncanonical mechanism in which RTK-containing endocytic vesicles deliver extracellular glucose to hexokinases associated with the outer mitochondrial membrane, thereby promoting cellular glucose uptake. Dysfunction linkage: functional impairment; cancer; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma
- biorxiv2026-08-06score 66mitochondrial dynamicsredox biologymetabolism
A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis
Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis: Conditional Emergence of Coordinated Disruption under the Gate Condition
- biorxiv2026-07-27score 45therapeuticsredox biologycancer
Why this mitochondrial dysfunction preprint matters: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Brea
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: dysfunction, disease context, cancer.
Source preprint: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast Cancer
- biorxiv2026-07-28score 43OXPHOStherapeuticscancer
Mitos importance brief: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Tr
This biorxiv preprint matters for mitochondria agents because it engages OXPHOS, therapeutics, cancer. Dysfunction-adjacent signals: OXPHOS / ETC, cancer.
Source preprint: Mitochondrial Oxygen Consumption Drives Lung Tumor Hypoxia and Resistance to Therapy via Copy Number Alteration in Mitochondrial Electron Transport Subunit NDUFB5
- biorxiv2026-07-27score 33mtDNAredox biologycancer
Mitos importance brief: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)
This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, cancer. Dysfunction-adjacent signals: mtDNA, cancer.
Source preprint: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)
- biorxiv2026-07-30score 29therapeuticsredox biologycancer
Mitos importance brief: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: cancer.
Source preprint: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation
- biorxiv2026-07-28score 29therapeuticscancer
Mitos importance brief: Doxycycline Modulates Uveal-Melanoma-Associated Marker Expression in BAP1-Repressed Human Ocular Organoids
This biorxiv preprint matters for mitochondria agents because it engages therapeutics, cancer. Dysfunction-adjacent signals: cancer.
Source preprint: Doxycycline Modulates Uveal-Melanoma-Associated Marker Expression in BAP1-Repressed Human Ocular Organoids