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computational mitochondria briefs

22 importance briefs tagged computational, including the current week and the archive.

• biorxiv2026-07-31score 83

  Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)

  Scientific focus: redox biology, metabolism, therapeutics, computational. Core claim (from abstract): Metabolic perturbation, mitochondrial dysfunction, and oxidative stress are key contributors to FSHD pathology. Dysfunction linkage: mitochondrial dysfunction; oxidative stress; reactive oxygen species; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 82

  The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy

  Scientific focus: cardiovascular, structural biology, computational. Core claim (from abstract): Variants in SMYD1, a striated muscle-specific lysine methyltransferase critical for cardiac development and mitochondrial function, have only recently been linked to human cardiomyopathy. Dysfunction linkage: mitochondrial dysfunction; functional impairment; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-07score 78

  Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

  Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 76

  Loss of neurofibromin alters adult metabolism via effects during a developmental critical period

  Scientific focus: OXPHOS, redox biology, metabolism, neurobiology. Core claim (from abstract): Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). Dysfunction linkage: OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-06score 75

  Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response

  Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Among the many subtypes of Charcot–Marie–Tooth (CMT) disease, several result from mutations in genes encoding aminoacyl–tRNA synthetases, enzymes required for tRNA charging during cytoplasmic and mitochondrial translation. Dysfunction linkage: molecular/genetic defect; disease context; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 75

  Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure

  Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Oxidation of ethanol by alcohol dehydrogenase (ADH) consumes nicotinamide adenine dinucleotide (NAD) while generating NADH, shifting the intracellular redox state toward a highly reduced environment that impairs mitochondrial function, limits endogenous aldehyde dehydrogenase (ALDH)-mediated acetaldehyde clearance, and promotes oxidative stress and tissue injury. Dysfunction linkage: functional impairment; oxidative stress; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 73

  A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut…

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): Background Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communication. Dysfunction linkage: functional impairment; disease context; inflammation; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 69

  The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface

  Scientific focus: redox biology, aging, computational. Core claim (from abstract): CHCHD10 is a mitochondrial protein genetically and pathologically linked to TDP-43 dysfunction, but the molecular basis connecting both proteins has remained unclear. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-31score 69

  Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs

  Scientific focus: immunology, structural biology, computational. Core claim (from abstract): Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs. Dysfunction linkage: functional impairment; molecular/genetic defect. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 68

  Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

  Scientific focus: therapeutics, structural biology, computational. Core claim (from abstract): We hypothesized that sequence-level adaptations evolved to balance these constraints. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 67

  A single Omicron mutation reshapes ORF3a-driven host-cell remodelling

  Scientific focus: metabolism, aging, structural biology, computational. Core claim (from abstract): Here, we combine complementary imaging approaches to define ORF3a function at nanometric scale, identifying underlying mechanisms, and determining how Omicron variant rewire this activity. Dysfunction linkage: aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 66

  A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 65

  Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans

  Scientific focus: redox biology, critical care, computational. Core claim (from abstract): As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 65

  Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ense…

  Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Results We systematically optimized sample preparation for untargeted LC-MS metabolomics of SECM using human serum as a reference. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-08-03score 65

  A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)

  Scientific focus: redox biology, computational. Core claim (from abstract): We are currently experiencing the largest recorded outbreak in USA history during the summer of 2026. Dysfunction linkage: disease context. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory

  Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 64

  Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): This increase in brain size evolved alongside advanced cognitive abilities as well as an elevated energetic demand. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 62

  CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides

  Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Here, we present CPPLocPred, a hierarchical machine-learning (ML) framework that predicts CPPs and their subcellular localization. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 60

  QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data

  Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 57

  Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension

  Scientific focus: redox biology, cardiovascular, computational. Core claim (from abstract): Methods: We collected 32 human RV tissue biopsies from patients with idiopathic PAH, systemic sclerosis-associated PAH (SSc-PAH), systemic sclerosis without pulmonary hypertension, with 24 nonfailing donor RVs serving as controls. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-31score 55

  MitoDate: a Nextflow pipeline for molecular clock dating and phylogenetic inference using ancient mitogenomes

  Scientific focus: computational. Core claim (from abstract): In cases where complete mitochondrial genomes (mitogenomes) can be recovered from such samples, Bayesian molecular clock dating approaches are routinely used as an alternative method for estimating their age. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-05score 48

  A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii

  Scientific focus: metabolism, structural biology, computational. Core claim (from abstract): Yet, little is known about the makeup or function of their MCSs, leaving a gap in our understanding of how organelles communicate beyond conventional model eukaryotes. Dysfunction linkage: disease context. Lower priority within the current window unless the topic matches a narrow research focus.

Also: redox biology · metabolism · therapeutics · structural biology · immunology · aging · neurobiology · cancer