Topics · structural biology

structural biology mitochondria briefs

14 importance briefs tagged structural biology, including the current week and the archive.

• biorxiv2026-08-03score 93

  Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…

  Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-08-06score 86

  GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype

  Scientific focus: OXPHOS, metabolism, therapeutics, structural biology. Core claim (from abstract): Objectives To characterize the hepatic histological, ultrastructural, and molecular phenotype of GRO at bariatric surgery, determine its recovery following surgery, and identify preoperative hepatic biomarkers associated with postoperative weight loss. Dysfunction linkage: mitochondrial dysfunction; OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-08-03score 83

  Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

  Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 82

  The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy

  Scientific focus: cardiovascular, structural biology, computational. Core claim (from abstract): Variants in SMYD1, a striated muscle-specific lysine methyltransferase critical for cardiac development and mitochondrial function, have only recently been linked to human cardiomyopathy. Dysfunction linkage: mitochondrial dysfunction; functional impairment; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-06score 72

  Stress granule fusion is a mitochondria-coordinated process for stress adaptation

  Scientific focus: mitochondrial dynamics, structural biology. Core claim (from abstract): Here, we show that stress granule fusion is facilitated by mitochondrial dynamics and membrane potential. Dysfunction linkage: functional impairment; cell death; dynamics (fission/fusion). Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-31score 69

  Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs

  Scientific focus: immunology, structural biology, computational. Core claim (from abstract): Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs. Dysfunction linkage: functional impairment; molecular/genetic defect. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 68

  Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

  Scientific focus: therapeutics, structural biology, computational. Core claim (from abstract): We hypothesized that sequence-level adaptations evolved to balance these constraints. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 67

  A single Omicron mutation reshapes ORF3a-driven host-cell remodelling

  Scientific focus: metabolism, aging, structural biology, computational. Core claim (from abstract): Here, we combine complementary imaging approaches to define ORF3a function at nanometric scale, identifying underlying mechanisms, and determining how Omicron variant rewire this activity. Dysfunction linkage: aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 66

  A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 66

  Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, aging. Core claim (from abstract): In this work, we demonstrate deep-ultraviolet (UV) microscopy as a powerful, label-free, high-resolution approach for quantifying multiscale intracellular dynamics with biomolecular specificity. Dysfunction linkage: disease context; aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 60

  QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data

  Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 60

  Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy

  Scientific focus: redox biology, aging, structural biology. Core claim (from abstract): Modern advances in using neural networks to learn continuous implicit representations of complex shapes present a promising solution to this problem. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 55

  Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain

  Scientific focus: structural biology. Core claim (from abstract): Here, we report the analysis of genome-wide data for 534 individuals from the Arras Culture of Middle Iron Age northeast England (including 390 from Wetwang Slack, 100 from Pocklington, and 29 from Melton), finding evidence for communities with kinship systems structured along matrilineal lines. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-05score 48

  A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii

  Scientific focus: metabolism, structural biology, computational. Core claim (from abstract): Yet, little is known about the makeup or function of their MCSs, leaving a gap in our understanding of how organelles communicate beyond conventional model eukaryotes. Dysfunction linkage: disease context. Lower priority within the current window unless the topic matches a narrow research focus.

Also: redox biology · computational · metabolism · therapeutics · immunology · aging · neurobiology · cancer