Topics · immunology

immunology mitochondria briefs

11 importance briefs tagged immunology, including the current week and the archive.

• biorxiv2026-08-03score 93

  Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…

  Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-03score 82

  Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, immunology. Core claim (from abstract): In pancreas tissue from donors across the natural history of T1D, we utilized an in-situ, whole - islet phenotypical and transcriptomic approach to unravel novel targets in the glucose-stimulus coupled secretion pathway that are similarly impaired in T-cell infiltrated and non-infiltrated islets. Dysfunction linkage: mitochondrial dysfunction; functional impairment; bioenergetics; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-07score 78

  Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

  Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-04score 78

  Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma

  Scientific focus: apoptosis, metabolism, immunology, cancer. Core claim (from abstract): Here we report that peripheral CD8⁺ T lymphocytes in osteosarcoma patients are less frequent in circulation, hypo-producers of effector cytokines (IFN-γ and TNF-α), and have compromised metabolic fitness․ We characterized and investigated the effect of a panel of microbiota-derived GAMs on CD8⁺ T lymphocytes, confirming their immunomodulatory role with respect to CD8⁺ T lymphocytes activation, cellular metabolism and effector functions․ Indole-3-lactic acid (ILA; product of tryptophan metabolism), was observed to be the strongest immunostimulant among all the GAMs studied. Dysfunction linkage: mitochondrial dysfunction; functional impairment; cell death; cancer. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 73

  A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut…

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): Background Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communication. Dysfunction linkage: functional impairment; disease context; inflammation; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 72

  SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation

  Scientific focus: apoptosis, redox biology, metabolism, immunology. Core claim (from abstract): Building on our previous finding that SAMHD1 promotes mitochondrial membrane damage in HIV-1-infected monocytic cells, here we identify a new function for SAMHD1 in enhancing HIV-1-induced glycolysis through upregulation of hexokinase 2 (HK2). Dysfunction linkage: organelle damage; oxidative stress; reactive oxygen species; cell death. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-07-31score 69

  Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs

  Scientific focus: immunology, structural biology, computational. Core claim (from abstract): Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs. Dysfunction linkage: functional impairment; molecular/genetic defect. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-08-03score 68

  Analgesic Efficacy of Native Himalayan Shilajit as Add-On Therapy in Myofascial Pain Syndrome: An Exploratory Pilot Clinical Trial

  Scientific focus: immunology, therapeutics. Core claim (from abstract): The main outcome was the percentage of participants with more than or equal to 30% VAS reduction at Day 49. Dysfunction linkage: bioenergetics; disease context. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory

  Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Decoding EGFR ligand bias through an endocytic organelle platform

  Scientific focus: metabolism, immunology. Core claim (from abstract): Here, we identify a receptor-proximal mechanism that links ligand-specific EGFR activation to distinct endocytic and biological outputs. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 64

  Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): This increase in brain size evolved alongside advanced cognitive abilities as well as an elevated energetic demand. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

Also: redox biology · computational · metabolism · therapeutics · structural biology · aging · neurobiology · cancer