Topics · redox biology

redox biology mitochondria briefs

42 importance briefs tagged redox biology, including the current week and the archive.

• biorxiv2026-08-03score 93

  Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…

  Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-29score 91

  Why this mitochondrial dysfunction preprint matters: Novel in vivo measurement of muscle total carnitine concentration reveals potential mechanism linking mitochondrial dysf

  This medrxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Dysfunction-adjacent signals: dysfunction, disease context.

• medrxiv2026-08-03score 83

  Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

  Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 83

  Metformin enhances differentiation and function of skeletal muscle in models of Facioscapulohumeral Muscular Dystrophy (FSHD)

  Scientific focus: redox biology, metabolism, therapeutics, computational. Core claim (from abstract): Metabolic perturbation, mitochondrial dysfunction, and oxidative stress are key contributors to FSHD pathology. Dysfunction linkage: mitochondrial dysfunction; oxidative stress; reactive oxygen species; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-03score 82

  Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, immunology. Core claim (from abstract): In pancreas tissue from donors across the natural history of T1D, we utilized an in-situ, whole - islet phenotypical and transcriptomic approach to unravel novel targets in the glucose-stimulus coupled secretion pathway that are similarly impaired in T-cell infiltrated and non-infiltrated islets. Dysfunction linkage: mitochondrial dysfunction; functional impairment; bioenergetics; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-30score 81

  Why this mitochondrial dysfunction preprint matters: Data-Driven Biological Subtypes of Parkinson ′ s Disease

  This medrxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, aging. Dysfunction-adjacent signals: dysfunction, mtDNA, disease context, neurodegeneration.

• biorxiv2026-08-07score 78

  Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegeneration

  Scientific focus: redox biology, neurobiology, immunology, aging. Core claim (from abstract): Elevated intracellular NM levels have been linked to neurodegeneration and PD-like phenotypes in experimental models. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-29score 77

  Why this mitochondrial dysfunction preprint matters: Assessment of Glucose Metabolism In Vivo in the Human Frontal Lobe Using Interleaved 1 H and 13 C MRS at 7T: Toward Clin

  This medrxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: dysfunction, disease context, neurodegeneration.

• biorxiv2026-08-01score 76

  Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization

  Scientific focus: mitophagy, redox biology, metabolism. Core claim (from abstract): Here, we identify multiple sequence elements that compromise the matrix localization of the phosphatase PPTC7 to facilitate its accumulation at the outer mitochondrial membrane (OMM), where it regulates mitophagy. Dysfunction linkage: mitophagy. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 76

  Loss of neurofibromin alters adult metabolism via effects during a developmental critical period

  Scientific focus: OXPHOS, redox biology, metabolism, neurobiology. Core claim (from abstract): Neurofibromatosis type 1 (OMIM 162200) is a genetic disorder that results from mutations in the NF1 gene and its encoded neurofibromin protein (Nf1). Dysfunction linkage: OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-06score 75

  Pharmacologic eIF2B Activation Rescues Neuropathy in CMT2 Subtypes by Normalizing the Integrated Stress Response

  Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Among the many subtypes of Charcot–Marie–Tooth (CMT) disease, several result from mutations in genes encoding aminoacyl–tRNA synthetases, enzymes required for tRNA charging during cytoplasmic and mitochondrial translation. Dysfunction linkage: molecular/genetic defect; disease context; neurodegeneration. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-05score 75

  Endocytosis of ALK promotes glucose uptake in ALK -amplified neuroblastoma

  Scientific focus: redox biology, metabolism, cancer, genetics. Core claim (from abstract): We recently identified a noncanonical mechanism in which RTK-containing endocytic vesicles deliver extracellular glucose to hexokinases associated with the outer mitochondrial membrane, thereby promoting cellular glucose uptake. Dysfunction linkage: functional impairment; cancer; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 75

  Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure

  Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Oxidation of ethanol by alcohol dehydrogenase (ADH) consumes nicotinamide adenine dinucleotide (NAD) while generating NADH, shifting the intracellular redox state toward a highly reduced environment that impairs mitochondrial function, limits endogenous aldehyde dehydrogenase (ALDH)-mediated acetaldehyde clearance, and promotes oxidative stress and tissue injury. Dysfunction linkage: functional impairment; oxidative stress; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-31score 73

  A Grape Seed Oligomeric Procyanidin Extract Reverses Diet-Induced Obesity Through Gut Microbiota Remodeling and Restoration of GLP-1, Gut…

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): Background Obesity is a complex multifactorial disease associated with chronic low grade inflammation, gut microbiota dysbiosis, and impaired gut-brain communication. Dysfunction linkage: functional impairment; disease context; inflammation; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 72

  SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation

  Scientific focus: apoptosis, redox biology, metabolism, immunology. Core claim (from abstract): Building on our previous finding that SAMHD1 promotes mitochondrial membrane damage in HIV-1-infected monocytic cells, here we identify a new function for SAMHD1 in enhancing HIV-1-induced glycolysis through upregulation of hexokinase 2 (HK2). Dysfunction linkage: organelle damage; oxidative stress; reactive oxygen species; cell death. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 69

  The ALS/FTD-linked protein CHCHD10 associates with the TDP-43 C-terminal domain through a CHCH-helix interface

  Scientific focus: redox biology, aging, computational. Core claim (from abstract): CHCHD10 is a mitochondrial protein genetically and pathologically linked to TDP-43 dysfunction, but the molecular basis connecting both proteins has remained unclear. Dysfunction linkage: mitochondrial dysfunction; disease context; aging; neurodegeneration. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 66

  A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 66

  Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics

  Scientific focus: mitochondrial dynamics, redox biology, metabolism, aging. Core claim (from abstract): In this work, we demonstrate deep-ultraviolet (UV) microscopy as a powerful, label-free, high-resolution approach for quantifying multiscale intracellular dynamics with biomolecular specificity. Dysfunction linkage: disease context; aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 65

  Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans

  Scientific focus: redox biology, critical care, computational. Core claim (from abstract): As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 65

  Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ense…

  Scientific focus: redox biology, metabolism, computational. Core claim (from abstract): Results We systematically optimized sample preparation for untargeted LC-MS metabolomics of SECM using human serum as a reference. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-08-03score 65

  A map of the historical spread of Cyclospora cayetanensis with a focus on the United States of America (USA)

  Scientific focus: redox biology, computational. Core claim (from abstract): We are currently experiencing the largest recorded outbreak in USA history during the summer of 2026. Dysfunction linkage: disease context. Moderate priority: useful for specialists in the listed topics.

• medrxiv2026-07-31score 65

  TruBlk TM Shilajit Resin Supplementation Improves Muscle Strength, Endurance, and Exercise Recovery in Males Undertaking Resistance Train…

  Scientific focus: redox biology, metabolism, therapeutics. Core claim (from abstract): Prior controlled trials have demonstrated increases in testosterone and retention of muscular strength with purified shilajit, though large trials in resistance-trained populations have been absent. Dysfunction linkage: organelle damage. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory

  Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 64

  Cross-species neural co-culture uncovers metabolic signatures of cellular crosstalk

  Scientific focus: redox biology, metabolism, neurobiology, immunology. Core claim (from abstract): This increase in brain size evolved alongside advanced cognitive abilities as well as an elevated energetic demand. Dysfunction linkage: systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 63

  Mitochondrial phosphate carrier-dependence of mitochondrial calcium chelation and respiration in skeletal muscle

  Scientific focus: calcium signaling, redox biology. Core claim (from abstract): Thus, PiC, the major mitochondrial Pi transporter, is well-positioned to regulate mitochondrial Ca 2+ handling. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 62

  CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides

  Scientific focus: redox biology, therapeutics, computational. Core claim (from abstract): Here, we present CPPLocPred, a hierarchical machine-learning (ML) framework that predicts CPPs and their subcellular localization. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 60

  QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data

  Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 60

  Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy

  Scientific focus: redox biology, aging, structural biology. Core claim (from abstract): Modern advances in using neural networks to learn continuous implicit representations of complex shapes present a promising solution to this problem. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-01score 57

  Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension

  Scientific focus: redox biology, cardiovascular, computational. Core claim (from abstract): Methods: We collected 32 human RV tissue biopsies from patients with idiopathic PAH, systemic sclerosis-associated PAH (SSc-PAH), systemic sclerosis without pulmonary hypertension, with 24 nonfailing donor RVs serving as controls. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-07score 47

  FIDDL: depth-matched negative controls distinguish genuine interspecific introgression from competitive-mapping artifact

  Scientific focus: redox biology. Core claim (from abstract): Using strains that cannot contain the ancestry being detected, we show this design generates substantial false-positive signal through two mechanisms with opposite phylogenetic-distance signatures. Dysfunction linkage: not strongly labeled in the abstract. Lower priority within the current window unless the topic matches a narrow research focus.

• biorxiv2026-07-27score 45

  Why this mitochondrial dysfunction preprint matters: Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Brea

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: dysfunction, disease context, cancer.

• biorxiv2026-07-29score 39

  Mitos importance brief: KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling

  This biorxiv preprint matters for mitochondria agents because it engages neurobiology, redox biology. Dysfunction-adjacent signals: ROS / oxidative stress.

• biorxiv2026-07-27score 33

  Mitos importance brief: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, cancer. Dysfunction-adjacent signals: mtDNA, cancer.

• biorxiv2026-07-30score 29

  Mitos importance brief: Deciphering the Effect of Melittin on Murine Cervical Cancer Cells Based on Transcriptomic Investigation

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology, cancer. Dysfunction-adjacent signals: cancer.

• biorxiv2026-07-29score 29

  Mitos importance brief: Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology. Dysfunction-adjacent signals: mtDNA.

• biorxiv2026-07-29score 29

  Mitos importance brief: A human cytokine response atlas to reconstruct underlying gene regulatory networks

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Dysfunction-adjacent signals: disease context.

• biorxiv2026-07-29score 29

  Mitos importance brief: Dimerization-dependent cis -autophosphorylation activates the UPR and ISR kinases

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Dysfunction-adjacent signals: ROS / oxidative stress.

• biorxiv2026-08-06score 25

  Mitos importance brief: Structural cell biology by mega-expansion microscopy

  This biorxiv preprint matters for mitochondria agents because it engages redox biology, aging. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-30score 25

  Mitos importance brief: Unraveling Wheat Aphid Diversity in Bangladesh Through Integrative Genetic and Morphological Approaches

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-27score 25

  Mitos importance brief: Integrative taxonomy reveals cryptic diversity in Chilean Trichomycterinae (Siluriformes, Trichomycteridae)

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-27score 25

  Mitos importance brief: Nutrient flux governs osteogenic fate commitment through the SLC3A1-cystine Axis

  This biorxiv preprint matters for mitochondria agents because it engages therapeutics, redox biology. Framing is largely mechanistic rather than explicit pathology.

• biorxiv2026-07-26score 25

  Mitos importance brief: Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of Wh

  This biorxiv preprint matters for mitochondria agents because it engages redox biology. Framing is largely mechanistic rather than explicit pathology.

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