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Mitochondria importance articles
Abstract-level scientific briefs on mitochondria preprints—structured for researchers and agents. Free in the browser. Machine JSON remains available via x402 for bots.
15 of 77 articles · updated 2026-08-08T16:01Z
- biorxiv2026-08-04score 93OXPHOSredox biologyneurobiology
Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction
Scientific focus: OXPHOS, redox biology, neurobiology, structural biology. Core claim (from abstract): Here we show that elevated intracellular cholesterol in murine astrocytes expressing the Alzheimer’s disease risk variant APOE4 disrupts the inner mitochondrial membrane, manifesting as sparse, truncated cristae alongside an excess of cristae junction complexes. Dysfunction linkage: mitochondrial dysfunction; cell death; OXPHOS / ETC; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction
- biorxiv2026-08-03score 93redox biologymetabolismimmunology
Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of…
Scientific focus: redox biology, metabolism, immunology, cancer. Core claim (from abstract): We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and evaluated the therapeutic potential of activating the NAD⁺–Sirtuin axis. Dysfunction linkage: mitochondrial dysfunction; functional impairment; oxidative stress; inflammation. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation
- medrxiv2026-08-06score 86OXPHOSmetabolismtherapeutics
GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype
Scientific focus: OXPHOS, metabolism, therapeutics, structural biology. Core claim (from abstract): Objectives To characterize the hepatic histological, ultrastructural, and molecular phenotype of GRO at bariatric surgery, determine its recovery following surgery, and identify preoperative hepatic biomarkers associated with postoperative weight loss. Dysfunction linkage: mitochondrial dysfunction; OXPHOS / ETC; disease context; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype
- medrxiv2026-08-03score 83mtDNAOXPHOSredox biology
Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease
Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease
- biorxiv2026-07-31score 82cardiovascularstructural biologycomputational
The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy
Scientific focus: cardiovascular, structural biology, computational. Core claim (from abstract): Variants in SMYD1, a striated muscle-specific lysine methyltransferase critical for cardiac development and mitochondrial function, have only recently been linked to human cardiomyopathy. Dysfunction linkage: mitochondrial dysfunction; functional impairment; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.
Source preprint: The SMYD1 p.Asn101Ser is a partial loss-of-function variant that impairs mitochondrial function and leads to early-onset cardiomyopathy.
- biorxiv2026-08-06score 72mitochondrial dynamicsstructural biology
Stress granule fusion is a mitochondria-coordinated process for stress adaptation
Scientific focus: mitochondrial dynamics, structural biology. Core claim (from abstract): Here, we show that stress granule fusion is facilitated by mitochondrial dynamics and membrane potential. Dysfunction linkage: functional impairment; cell death; dynamics (fission/fusion). Moderate priority: useful for specialists in the listed topics.
Source preprint: Stress granule fusion is a mitochondria-coordinated process for stress adaptation
- biorxiv2026-07-31score 69immunologystructural biologycomputational
Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs
Scientific focus: immunology, structural biology, computational. Core claim (from abstract): Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs. Dysfunction linkage: functional impairment; molecular/genetic defect. Moderate priority: useful for specialists in the listed topics.
Source preprint: Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs
- biorxiv2026-08-07score 68therapeuticsstructural biologycomputational
Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution
Scientific focus: therapeutics, structural biology, computational. Core claim (from abstract): We hypothesized that sequence-level adaptations evolved to balance these constraints. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution
- biorxiv2026-08-04score 67metabolismagingstructural biology
A single Omicron mutation reshapes ORF3a-driven host-cell remodelling
Scientific focus: metabolism, aging, structural biology, computational. Core claim (from abstract): Here, we combine complementary imaging approaches to define ORF3a function at nanometric scale, identifying underlying mechanisms, and determining how Omicron variant rewire this activity. Dysfunction linkage: aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A single Omicron mutation reshapes ORF3a-driven host-cell remodelling
- biorxiv2026-08-06score 66mitochondrial dynamicsredox biologymetabolism
A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis
Scientific focus: mitochondrial dynamics, redox biology, metabolism, cancer. Core claim (from abstract): Enzymatic cofactors occupy a uniquely fundamental position within this architecture: they enable catalytic activity itself. Dysfunction linkage: cancer; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: A Multiscale Computational Framework for the Mg-28 Radio-Cofactor Hypothesis: Conditional Emergence of Coordinated Disruption under the Gate Condition
- biorxiv2026-08-04score 66mitochondrial dynamicsredox biologymetabolism
Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics
Scientific focus: mitochondrial dynamics, redox biology, metabolism, aging. Core claim (from abstract): In this work, we demonstrate deep-ultraviolet (UV) microscopy as a powerful, label-free, high-resolution approach for quantifying multiscale intracellular dynamics with biomolecular specificity. Dysfunction linkage: disease context; aging; systemic metabolic stress. Moderate priority: useful for specialists in the listed topics.
Source preprint: Deep-ultraviolet microscopy reveals biomolecular spatiotemporal intracellular dynamics
- biorxiv2026-08-07score 60redox biologyagingstructural biology
QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data
Scientific focus: redox biology, aging, structural biology, computational. Core claim (from abstract): Here we present QuantEM, an open-source platform for segmentation and analysis of EM data across imaging modalities, tissues, and species. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: QuantEM: An optimized platform of vision transformer-based models for segmentation and analysis of electron microscopy data
- biorxiv2026-08-04score 60redox biologyagingstructural biology
Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy
Scientific focus: redox biology, aging, structural biology. Core claim (from abstract): Modern advances in using neural networks to learn continuous implicit representations of complex shapes present a promising solution to this problem. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.
Source preprint: Physics-Guided Neural Reconstruction of Cellular Membranes for 3D Electron Microscopy
- biorxiv2026-08-06score 55structural biology
Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain
Scientific focus: structural biology. Core claim (from abstract): Here, we report the analysis of genome-wide data for 534 individuals from the Arras Culture of Middle Iron Age northeast England (including 390 from Wetwang Slack, 100 from Pocklington, and 29 from Melton), finding evidence for communities with kinship systems structured along matrilineal lines. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.
Source preprint: Ancient DNA reveals matrilineal organisation and recurrent unions between dominant matrilines in Iron Age Britain
- biorxiv2026-08-05score 48metabolismstructural biologycomputational
A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii
Scientific focus: metabolism, structural biology, computational. Core claim (from abstract): Yet, little is known about the makeup or function of their MCSs, leaving a gap in our understanding of how organelles communicate beyond conventional model eukaryotes. Dysfunction linkage: disease context. Lower priority within the current window unless the topic matches a narrow research focus.
Source preprint: A proximity biotinylation approach for the identification of membrane contact site proteins in Toxoplasma gondii