Topics · apoptosis

apoptosis mitochondria briefs

3 importance briefs tagged apoptosis, including the current week and the archive.

• biorxiv2026-08-04score 78

  Gut-Associated Metabolites (GAMs) revitalize dysfunctional CD8⁺ T lymphocytes in Osteosarcoma

  Scientific focus: apoptosis, metabolism, immunology, cancer. Core claim (from abstract): Here we report that peripheral CD8⁺ T lymphocytes in osteosarcoma patients are less frequent in circulation, hypo-producers of effector cytokines (IFN-γ and TNF-α), and have compromised metabolic fitness․ We characterized and investigated the effect of a panel of microbiota-derived GAMs on CD8⁺ T lymphocytes, confirming their immunomodulatory role with respect to CD8⁺ T lymphocytes activation, cellular metabolism and effector functions․ Indole-3-lactic acid (ILA; product of tryptophan metabolism), was observed to be the strongest immunostimulant among all the GAMs studied. Dysfunction linkage: mitochondrial dysfunction; functional impairment; cell death; cancer. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-08-04score 72

  SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation

  Scientific focus: apoptosis, redox biology, metabolism, immunology. Core claim (from abstract): Building on our previous finding that SAMHD1 promotes mitochondrial membrane damage in HIV-1-infected monocytic cells, here we identify a new function for SAMHD1 in enhancing HIV-1-induced glycolysis through upregulation of hexokinase 2 (HK2). Dysfunction linkage: organelle damage; oxidative stress; reactive oxygen species; cell death. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 63

  A p32 family RNA editing factor acts in mitochondrial ribosome biogenesis

  Scientific focus: apoptosis, biogenesis. Core claim (from abstract): Here, using genetic modifications and proteomic characterization of the immunoprecipitated assemblosome, the earliest characterized mtSSU precursor, we determined that a cap of its distinctive protrusion of hitherto unknown composition consists of a p22 homotrimer. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

Also: redox biology · computational · metabolism · therapeutics · structural biology · immunology · aging · neurobiology