Topics · biogenesis

biogenesis mitochondria briefs

3 importance briefs tagged biogenesis, including the current week and the archive.

• biorxiv2026-08-04score 77

  FAM136A is an essential chaperone for mitochondrial membrane protein biogenesis

  Scientific focus: OXPHOS, biogenesis, metabolism, genetics. Core claim (from abstract): ABSTRACT The metabolic and signaling function of mitochondria rely on a network of chaperones within the inner membrane space (IMS) that regulate the biogenesis of nascent mitochondrial proteins. Dysfunction linkage: OXPHOS / ETC; systemic metabolic stress. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• biorxiv2026-07-28score 76

  Corilagin saves glutathione, membrane potential, and the AMPK-TFAM axis in high-glucose neuroblastoma cells

  In SH-SY5Y cells, 50 mM glucose for 24 hours depletes reduced glutathione, raises intracellular and mitochondrial reactive oxygen species, drops membrane potential, fragments the network, and increases cell death. Corilagin pretreatment opposes each of those changes and restores AMPK phosphorylation plus SIRT1, PGC-1α, and TFAM. The named redox species is reduced glutathione, one side of the GSH/GSSG couple. No metal site is identified. The abstract's wider disease framing (diabetic nephropathy, cerebral ischemia) is not the experiment it describes.

• biorxiv2026-08-04score 63

  A p32 family RNA editing factor acts in mitochondrial ribosome biogenesis

  Scientific focus: apoptosis, biogenesis. Core claim (from abstract): Here, using genetic modifications and proteomic characterization of the immunoprecipitated assemblosome, the earliest characterized mtSSU precursor, we determined that a cap of its distinctive protrusion of hitherto unknown composition consists of a p22 homotrimer. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

Also: redox biology · computational · metabolism · therapeutics · structural biology · immunology · aging · neurobiology