Topics · critical care

critical care mitochondria briefs

3 importance briefs tagged critical care, including the current week and the archive.

• biorxiv2026-08-04score 72

  SAMHD1 enhances HIV-1-induced glycolysis in monocytic cells through hexokinase 2 upregulation

  Scientific focus: apoptosis, redox biology, metabolism, immunology. Core claim (from abstract): Building on our previous finding that SAMHD1 promotes mitochondrial membrane damage in HIV-1-infected monocytic cells, here we identify a new function for SAMHD1 in enhancing HIV-1-induced glycolysis through upregulation of hexokinase 2 (HK2). Dysfunction linkage: organelle damage; oxidative stress; reactive oxygen species; cell death. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-06score 65

  Lysosome-related organelle genes are required for mitochondrial transformations during bacterial infections in Caenorhabditis elegans

  Scientific focus: redox biology, critical care, computational. Core claim (from abstract): As bacteria-derived organelles, mitochondria carry lipids, proteins, and other molecules such as iron which are required for bacterial growth, and thus are subject to pathogenic bacterial attack. Dysfunction linkage: not strongly labeled in the abstract. Moderate priority: useful for specialists in the listed topics.

• biorxiv2026-08-04score 64

  Single-cell transcriptomics reveals a multiphasic Wolbachia host infection trajectory

  Scientific focus: redox biology, immunology, aging, critical care. Core claim (from abstract): Here we used single-cell RNA sequencing to examine how w Mel colonization reshapes the host transcriptome during establishment of stable infection in D. melanogaster JW18 cell lines. Dysfunction linkage: aging. Moderate priority: useful for specialists in the listed topics.

Also: redox biology · computational · metabolism · therapeutics · structural biology · immunology · aging · neurobiology