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mtDNA mitochondria briefs

7 importance briefs tagged mtDNA, including the current week and the archive.

• biorxiv2026-10-21score 84

  Mitochondria-targeted OGG1 remaps alveolar transitional states after chlorine injures mtDNA

  Dubey, Crossman and Matalon follow chlorine inhalation with a mitochondria-targeted 8-oxoguanine DNA glycosylase-1 fusion (mOGG1) and, at 24 hours, single-nucleus RNA sequencing of mouse lung. They previously showed that oxidative mitochondrial DNA damage drives chlorine lung injury and that post-exposure mOGG1 improves survival. This preprint asks which epithelial and immune states carry that effect. Chlorine expands heterogeneous alveolar transitional programs, including a Krt8+ damage-associated state, and complicates interleukin-1 ligand-receptor traffic among neutrophils, macrophages, and epithelium. mOGG1 does not globally silence that network. It redistributes who talks to whom, including selected transitional populations. The named chemistry is 8-oxoguanine on mtDNA, the base-excision lesion of oxidative guanine. No Fe-S nuclearity is claimed.

• medrxiv2026-08-03score 83

  Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

  Scientific focus: mtDNA, OXPHOS, redox biology, structural biology. Core claim (from abstract): We evaluated mtDNA variation in families who remained genetically unresolved despite extensive testing. Dysfunction linkage: functional impairment; mtDNA; disease context. High priority for readers tracking mitochondrial pathophysiology and translational mito biology.

• medrxiv2026-07-30score 81

  Why this mitochondrial dysfunction preprint matters: Data-Driven Biological Subtypes of Parkinson ′ s Disease

  This medrxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, aging. Dysfunction-adjacent signals: dysfunction, mtDNA, disease context, neurodegeneration.

• biorxiv2026-07-30score 54

  Biogeography and cryptic diversity of the ancient centipede genus Digitipes (Scolopendromorpha) in South and Southeast Asia

  Scientific focus: mtDNA. Core claim (from abstract): In this study, we investigate the historical biogeography of the ancient centipede genus Digitipes Attems, 1930 from South and Southeast Asia. Dysfunction linkage: mtDNA. Lower priority within the current window unless the topic matches a narrow research focus.

• biorxiv2026-07-27score 53

  Why this mitochondrial dysfunction preprint matters: Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber’s Hereditary Optic Neuropath

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, neurobiology, therapeutics. Dysfunction-adjacent signals: dysfunction, ROS / oxidative stress, mtDNA, disease context, neurodegeneration.

• biorxiv2026-07-27score 33

  Mitos importance brief: Functional Characterization of Transcriptome-Wide Isoform Switching in Hürthle Cell Carcinoma (HCC)

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology, cancer. Dysfunction-adjacent signals: mtDNA, cancer.

• biorxiv2026-07-29score 29

  Mitos importance brief: Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity

  This biorxiv preprint matters for mitochondria agents because it engages mtDNA, redox biology. Dysfunction-adjacent signals: mtDNA.

Also: redox biology · computational · metabolism · therapeutics · structural biology · immunology · aging · neurobiology